Results 111 to 120 of about 145,230 (316)

The EXPLAIN Study: Exploring Arthrogryposis Multiplex Congenita in Adults in Norway — A Description of Demographic, Medical, and Neurological Findings

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis Multiplex Congenita (AMC) encompasses several hundred conditions with diverse genetic, pathophysiological, and clinical origins. The overarching EXPLAIN study explores underlying causes and implications of AMC and represents the largest clinical cohort of adults with AMC reported to date.
My Vuong Hermansen, Kristin Ørstavik, Unni Steen, Mathias Toft, Cathrine Brunborg, Lena Lande Wekre   +5 more
wiley   +1 more source

Joint loading asymmetries in knee replacement patients observed both pre- and six months post-operation

BackgroundStudies have highlighted asymmetries in knee joint moments during activities of daily living in individuals with osteoarthritis and joint replacements.
Stokes, M., Taylor, M., Worsley, Peter, Barrett, D.S.   +3 more
core   +1 more source

Knee adduction moment and medial contact force - facts about their correlation during gait

, 2013
The external knee adduction moment is considered a surrogate measure for the medial tibiofemoral contact force and is commonly used to quantify the load reducing effect of orthopedic interventions. However, only limited and controversial data exist about
Bergmann, Georg, Georg Bergmann, Adam Trepczynski, Markus O Heller, Kutzner, Ines, Trepczynski, Adam, Heller, Markus O., Ines Kutzner   +7 more
core   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Anti‐inflammatory and osteogenic effects of transcutaneous electrical nerve stimulation in knee osteoarthritis rats via the regulation of the intestinal microbiota

Animal Models and Experimental Medicine, EarlyView.
Transcutaneous electrical nerve stimulation (TENS) improved knee osteoarthritis (KOA) in rats by regulating interleukin‐1β (IL‐1β), IL‐6, and IL‐8 expressions and the bone morphogenetic protein 2 (BMP‐2)/transforming growth factor β (TGF‐β) signaling pathway.
Yan Sun, Tong Ma, Ran Chen, Lan Shen, Xun Tang, Zhiqiang Shen, Hongbin Zhao   +6 more
wiley   +1 more source

Knee osteoarthritis and obesity

International Journal of Obesity, 2001
To assess the risk of knee osteoarthritis (OA) attributable to obesity, and the interactions between obesity and other established causes of the disorder.We performed a population-based case-control study in three health districts of England (Southampton, Portsmouth and North Staffordshire).
Coggon, D., Reading, I., Croft, P., McLaren, M., Barrett, D.S., Cooper, C.   +5 more
openaire   +4 more sources

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

Notchplasty for the Arthroscopic Treatment of Limited Knee Extension

Arthroscopy Techniques, 2017
Knee osteoarthritis may lead to narrowing of the intercondylar notch due to osteophyte formation, thereby causing changes in native knee biomechanics.
Marcio B. Ferrari, M.D., Sandeep Mannava, M.D., Ph.D., Nicholas DePhillipo, M.S., A.T.C., George Sanchez, B.S., Robert F. LaPrade, M.D., Ph.D.   +4 more
doaj   +1 more source

Continuous Sewing Machine‐Like Suture Provides Higher Failure and Yield Load Compared to Traditional Techniques for Meniscal Root Repair in a Biomechanical Porcine Model

Arthroscopy, EarlyView.
Purpose To evaluate the biomechanical performance of the sewing machine‐like suture (SMS) technique against three established techniques (two cinch‐loop (TCL), modified Mason‐Allen (MMA), and double Mason‐Allen (DMA)) for transtibial pull‐out repair of posterior medial meniscal root tear (PMMRT) in a porcine model.
Yizhong Peng, Wenbo Yang, Yi Li, Chunqing Meng, Hong Wang, Wei Huang   +5 more
wiley   +1 more source

Editorial Commentary: LET's Keep Expanding Our Indications for Lateral Extra‐articular Procedures During Anterior Cruciate Ligament Reconstruction

Arthroscopy, EarlyView.
Abstract Anatomic anterior cruciate ligament reconstruction has been successful for many years in restoring translational stability, but have we done enough to restore rotational stability? Biomechanical evidence shows that anatomic anterior cruciate ligament reconstruction alone may not restore pivot shift stability in cadaveric models.
Nicholas A. Trasolini
wiley   +1 more source