Results 101 to 110 of about 145,230 (316)
, 2011 Osteoarthritis (OA) is one of the most common degenerative wear diseases of knee joints worldwide. Within knee joint articular cartilage (AC), collagen structure losing integrity is a major symptom of OA.
Jiang, X. +9 more
core +1 more source
Effects of a Custom-Made Hinged Knee Brace with Knee Flexion Support for Patients with Knee Osteoarthritis: A Preliminary Study [PDF]
, 2015 2015-02A knee brace for medial knee osteoarthritis (OA) is required to restrict knee adduction moment (KAM), but must not restrict knee flexion during swing phase. There is no report of a knee brace with both functions.
OTA, SUSUMU +5 more
core +1 more source
, 2009 Topical diclofenac sodium (pennsaid) is a non-steroidal-anti- inflammatory drug that is used to manage the recurrent pain and symptoms of osteoarthritis of the knee. Pennsaid is applied topically, absorbed cutaneously and concentrates locally at the site
Banning, M
core
Managing osteoarthritis of the knee [PDF]
BMJ, 2004 A slightly swollen and aching knee. Walking is difficult, the stairs are almost impossible, and so begins the downward spiral of inactivity, immobility, and weight gain. Osteoarthritis of the knee is a familiar picture, presenting usually when it is too painful to ignore but too early for surgery.
openaire +2 more sources
Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment
Advanced Science, EarlyView.Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen +15 more
wiley +1 more source
Dynamic knee joint mechanics after anterior cruciate ligament reconstruction.
, 2014 There is a scarcity of information on the long term adaptations in lower limb biomechanics during game specific movements after an anterior cruciate ligament (ACL) reconstruction.
Harrison, Andrew +16 more
core +1 more source
Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing
Advanced Science, EarlyView.Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan +13 more
wiley +1 more source
Physical Activity and the Role of Walking in Knee Osteoarthritis
, 2023 Walking is recommended as a type of physical activity for individuals with knee osteoarthritis, yet this population is physically inactive. The quantitative effects of walking exercise on joint health to inform walking prescription remain poorly ...
Budarick, Aleksandra
core
The relationship between foot and ankle symptoms and risk of developing knee osteoarthritis: data from the osteoarthritis initiative [PDF]
, 2017 ObjectiveTo investigate whether foot and/or ankle symptoms increase the risk of developing (1) knee symptoms and (2) symptomatic radiographic knee osteoarthritis (OA).Design1020 Osteoarthritis Initiative (OAI) participants who were at-risk of knee OA ...
core +1 more source