Results 171 to 180 of about 708,008 (375)

Exercise for osteoarthritis of the hip and knee [PDF]

, 2016
Howe, Tracey
core   +1 more source

Spontaneous osteoarthritis in Str/ort mice is unlikely due to greater vulnerability to mechanical trauma [PDF]

, 2013
B. Poulet, T.A.T. Westerhof, Rick Hamilton, Sandra J. Shefelbine, Andrew A. Pitsillides   +4 more
openalex   +1 more source

Inactivation of AXL in Cardiac Fibroblasts Alleviates Right Ventricular Remodeling in Pulmonary Hypertension

Advanced Science, EarlyView.
Pulmonary hypertension (PH) is a progressive condition with high morbidity and mortality, largely owing to right ventricular (RV) failure resulting from maladaptive remodeling. Our study provides strong evidence in support of a critical, detrimental role for AXL as a previously unrecognized determinant driving RV fibrotic pathology in PH.
Li‐Wei Wu, Min Chen, Chen‐Yu Jiang, Dai‐Ji Jiang, Xu Zhang, Xiao‐He Xu, Yi‐Wei Liu, Bei Feng, Lin‐Cai Ye, Yang‐Yang He, Xu Huang, Yi‐Chi Zhang, Xing‐Liang Zhou, Yi Shen, Tian‐Yu Liu, Li‐Jun Fu, Yi Yan, Hao Zhang   +17 more
wiley   +1 more source

MSC Membrane‐Coated circPROSC‐siRNA Nanoparticles for Ameliorating Craniosynostosis by Inhibiting Premature Suture Ossification

Advanced Science, EarlyView.
CircPROSC promotes craniosynostosis by sponging miR‐6815‐5p, thereby activating WNT3A/β‐catenin signaling and enhancing RUNX2‐mediated osteogenesis. Targeted silencing of circPROSC with MSC membrane–coated siRNA nanoparticles (MM@Lipo/si‐circPROSC) delivered postnatally into cranial sutures attenuates premature suture closure in Twist1+/– mice ...
Zhenkun Weng, Xiu Chen, Jin Xu, Qing Yan, Jian Jiao, Qian Liu, Aihua Gu   +6 more
wiley   +1 more source

Insights into osteoarthritis development from single-cell RNA sequencing of subchondral bone

RMD Open, 2022
Ping Shen, Max Löhning
doaj   +1 more source

Osteoarthritis patients exhibit an autonomic dysfunction with indirect sympathetic dominance

Journal of Translational Medicine
Background Osteoarthritis (OA) is a chronic degenerative joint disease causing limited mobility and pain, with no curative treatment available. Recent in vivo studies suggested autonomic alterations during OA progression in patients, yet clinical ...
Rebecca Sohn, Tina Assar, Isabelle Kaufhold, Marco Brenneis, Sebastian Braun, Marius Junker, Frank Zaucke, Georg Pongratz, Zsuzsa Jenei-Lanzl   +8 more
doaj   +1 more source

The role of mechanobiology in bone and cartilage model systems in characterizing initiation and progression of osteoarthritis

, 2022
Tom Hodgkinson, Isabel Amado, Fergal J. O’Brien, Oran D. Kennedy   +3 more
openalex   +1 more source

Roles for B[a]P and FICZ in subchondral bone metabolism and experimental temporomandibular joint osteoarthritis via the AhR/Cyp1a1 signaling axis [PDF]

, 2021
Yuri Yoshikawa, Takashi Izawa, Yusaku Hamada, Hiroko Takenaga, Ziyi Wang, Naozumi Ishimaru, Hiroshi Kamioka   +6 more
openalex   +1 more source

Multiscale 3D Whole Joint Cellular and Molecular Mapping Reveals Disease‐Specific Neurovascular Plasticity Underlying the Structure‐Pain Relationship

Advanced Science, EarlyView.
This study presents MUSIC, a novel immunostaining and clearing method coupled with large‐field light sheet microscopy, enabling 3D high‐resolution cellular and molecular mapping of intact musculoskeletal joints across species and joint types. Using joint degenerative and injury models, disease‐specific neurovascular alterations are uncovered, revealing
Peng Chen, Jiaxin Chai, Abirami Soundararajan, R. Glenn Hepfer, Benjamin Kheyfets, Jiaxin Hu, Ishraq Alshanqiti, Swarnalakshmi Raman, Ikue Tosa, Jun Tae Huh, Matthew Yee, Brooke J. Damon, Shangping Wang, Yu Shin Kim, Man‐Kyo Chung, Mildred C. Embree, Janice S. Lee, Tong Ye, Hai Yao   +18 more
wiley   +1 more source

Changes of bone turnover markers and bone mineral density among postmenopausal Thai women with osteoporosis receiving generic risedronate

BMC Women's Health
Background Osteoporosis has been recognized as a significant health issue in Thailand. Pharmacological interventions are important way to prevent fracture. However, one of the main challenges in selecting a medication is high cost, particularly for brand-
Ammarin Suwan, Chotetawan Tanavalee, Krasean Panyakhamlerd, Srihatach Ngarmukos, Suchanant Chavaengkiat, Aree Tanavalee, Chavarin Amarase, Thanapob Bumphenkiatikul   +7 more
doaj   +1 more source