Results 151 to 160 of about 313,441 (304)

A scoping review and guide for in vitro healthy human knee joint laxity

Frontiers in Bioengineering and Biotechnology
IntroductionKnee laxity is a well-studied concept with a vast repository of information in the literature. However, an often-overlooked challenge arises from the diverse methodological heterogeneity, making inter-study comparisons and overall knowledge ...
Bo Eitel Seiferheld, Bo Eitel Seiferheld, Martin Vorup Lindvald, Ilias Theodorakos, Brett Michael Musolf, Brett Michael Musolf, Morten Bilde Simonsen, Morten Bilde Simonsen, Michael Skipper Andersen, Michael Skipper Andersen, Mohammadjavad (Matin) Einafshar, Mohammadjavad (Matin) Einafshar   +11 more
doaj   +1 more source

Animal models in molecular biology research: Challenges, ethical imperatives, and the path to human‐relevant translation

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract shows how molecular biology research has shifted from using traditional animal models toward using methods that are more relevant to humans. It points out the main problems, differences between species, difficulty in reproducing results, moral issues, and lack of infrastructure that make translational accuracy harder to achieve ...
Md. Shajid Hossain Rafi, Md. Taslim Sarker, Ferdous‐Ul‐Haque Joy, Shahriar Mohd Shams, Tahmina Foyez, Md. Abdul Mazid, Syed Masudur Rahman Dewan   +6 more
wiley   +1 more source

Changes of bone turnover markers and bone mineral density among postmenopausal Thai women with osteoporosis receiving generic risedronate

BMC Women's Health
Background Osteoporosis has been recognized as a significant health issue in Thailand. Pharmacological interventions are important way to prevent fracture. However, one of the main challenges in selecting a medication is high cost, particularly for brand-
Ammarin Suwan, Chotetawan Tanavalee, Krasean Panyakhamlerd, Srihatach Ngarmukos, Suchanant Chavaengkiat, Aree Tanavalee, Chavarin Amarase, Thanapob Bumphenkiatikul   +7 more
doaj   +1 more source

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

Paleopathology of a putative colossosaurian caudal vertebra (Neosauropoda: Titanosauria) from the Presidente Prudente Formation, Brazil

The Anatomical Record, EarlyView.
Abstract Studies investigating paleopathologies in sauropods remain scarce despite their relative abundance in the fossil record. In this study we report new occurrence of paleopathological features, corresponding to a neoplasm found in a middle caudal vertebra (MCT.R.2120) of an advanced titanosaur from the Presidente Prudente Formation (Bauru Basin ...
Maria Luiza Peres Bertolossi, Kamila L. N. Bandeira, Roberta Veronese do Amaral, Arthur S. Brum, Rafael C. da Silva, Valéria Gallo   +5 more
wiley   +1 more source

The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a mendelian randomisation study

ObjectiveVariation in the fat mass and obesity-associated (FTO) gene influences susceptibility to obesity. A variant in the FTO gene has been implicated in genetic risk to osteoarthritis (OA).
Pannoutsopoulou, K., Wheeler, M., Jones, G., Spector, T.D., Laslett, L.L., Cicuttini, F.M., Cooper, C., Metrustry, S., Zhang, W., Doherty, S., Arden, N.K., Doherty, M., Valdes, A.M., Zeggini, E., Maciewicz, R.A., Hart, D.J., Muir, K.R.   +16 more
core   +1 more source

The petrotympanic canal (Huguier canal): Evolutionary, anatomical, and medical perspectives

The Anatomical Record, EarlyView.
Abstract The petrotympanic canal, traditionally referred to as Civinini's or Huguier's canal, represents an anatomical passage connecting the middle ear and temporomandibular joint (TMJ). Despite its early description, its structural complexity and functional significance have often been underestimated. In this study, we combined historical, anatomical,
Andrea Papini, Nicola Montemurro, Ferdinando Paternostro, Immacolata Belviso, Massimo Galli, Petra Martini, Licia Uccelli, Jacopo Moggi‐Cecchi, Gregorio Oxilia   +8 more
wiley   +1 more source

Multidisciplinary consensus on the management of patients with osteopenia and fracture risk in Spain

BMC Musculoskeletal Disorders
Background In Spain, over 3.5 million individuals are diagnosed with osteoporosis, while an even greater number are affected by osteopenia, the precursor stage of this severe condition.
Jose Luis Baquero Úbeda, Silvia García Díaz, Jesús-Carlos Gómez Martínez, Nina Martínez Fernández, Rafael Manuel Micó Pérez, Ingrid Möller, José Luis Neyro Bilbao, Pilar Saez López, Manuel Santiñà Vila, Josep Vergés Milano, Task Force Members   +10 more
doaj   +1 more source

Continuous Sewing Machine‐Like Suture Provides Higher Failure and Yield Load Compared to Traditional Techniques for Meniscal Root Repair in a Biomechanical Porcine Model

Arthroscopy, EarlyView.
Purpose To evaluate the biomechanical performance of the sewing machine‐like suture (SMS) technique against three established techniques (two cinch‐loop (TCL), modified Mason‐Allen (MMA), and double Mason‐Allen (DMA)) for transtibial pull‐out repair of posterior medial meniscal root tear (PMMRT) in a porcine model.
Yizhong Peng, Wenbo Yang, Yi Li, Chunqing Meng, Hong Wang, Wei Huang   +5 more
wiley   +1 more source

Partial Repair and Superior Capsular Reconstruction Both Improve Outcomes for Irreparable Posterosuperior Rotator Cuff Tears: A Systematic Review

Arthroscopy, EarlyView.
Purpose To synthesize patient‐reported outcome measures, failure rates, and mobility parameters for comparison of partial repair versus superior capsular reconstruction (SCR) in the treatment of irreparable posterosuperior rotator cuff tears. Methods EMBASE, OVID Medline, and Emcare were searched from database inception to November 2024 for studies on ...
Marc Daniel Bouchard, Cameron Pow, Matthew Macciacchera, Vanay Verma, Tinghua Zhang, Bogdan Matache   +5 more
wiley   +1 more source