Results 141 to 150 of about 313,441 (304)

Spinal Involvement in a Pediatric and Adult Cohort of Patients With Arthrogryposis Multiplex Congenita

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT This was a single‐center retrospective observational study with national recruitment from October 2007 to March 2022 at the AMC clinic of the University Hospital Grenoble Alpes (CHUGA). Participants underwent a clinical spinal assessment and spine radiography.
Alicia Mom, Véronique Bourg, Shenhao Dai, Alicia‐Marine Milot, Dominic Perennou, Klaus Dieterich   +5 more
wiley   +1 more source

The EXPLAIN Study: Exploring Arthrogryposis Multiplex Congenita in Adults in Norway — A Description of Demographic, Medical, and Neurological Findings

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis Multiplex Congenita (AMC) encompasses several hundred conditions with diverse genetic, pathophysiological, and clinical origins. The overarching EXPLAIN study explores underlying causes and implications of AMC and represents the largest clinical cohort of adults with AMC reported to date.
My Vuong Hermansen, Kristin Ørstavik, Unni Steen, Mathias Toft, Cathrine Brunborg, Lena Lande Wekre   +5 more
wiley   +1 more source

Impact of Kellgren–Lawrence grade on clinical outcomes following adipose-derived stem cell therapy for knee osteoarthritis: A propensity score–matched retrospective cohort study

Cell Transplantation
Knee osteoarthritis (OA) causes pain and disability, and autologous adipose-derived stem cell (ASC) therapy has emerged as a regenerative treatment option.
Naoki Nakano, Tomoyuki Matsumoto, Masanori Tsubosaka, Tomoyuki Kamenaga, Kazunari Ishida, Rinako Osaka, Masaki Otsuji, Norimasa Nakamura, Yuichi Kuroda, Shinya Hayashi, Ryosuke Kuroda   +10 more
doaj   +1 more source

Rationale, design and conduct of a comprehensive evaluation of a primary care based intervention to improve the quality of life of osteoarthritis patients. The PraxArt-project: a cluster randomized controlled trial [ISRCTN87252339] ; study protocol

, 2005
Background: Osteoarthritis (OA) has a high prevalence in primary care. Conservative, guideline orientated approaches aiming at improving pain treatment and increasing physical activity, have been proven to be effective in several contexts outside the ...
Gensichen, Jochen, Christiane Muth, Joachim Szecsenyi, Szecsenyi, Joachim, Rosemann, Thomas, Stefanie Joos, Thomas Rosemann, Wensing, Michel, Jochen Gensichen, Muth, Christiane, Körner, Thorsten, Thorsten Körner, Joos, Stefanie, Michel Wensing   +13 more
core   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Osteoarthritis Cartilage [PDF]

Objective:To better understand the pathogenesis of knee osteoarthritis (OA) through identification of serum diagnostics.Design:We conducted multiple reaction monitoring mass spectrometry analysis of 107 peptides in baseline sera of two cohorts: the ...

core  

Risk factors for meniscal body extrusion on MRI in subjects free of radiographic knee osteoarthritis: Longitudinal data from the Osteoarthritis initiative

, 2016
To determine risk factors associated with increased meniscal body extrusion on knee magnetic resonance (MR) images in subjects free of radiographic ...
Kumm, Jaanika, Turkiewicz, Aleksandra,, Svensson, Fredrik,, Frobell, Richard,, Englund, Martin,, Lund University., Zhang, Fan,   +6 more
core   +1 more source

Anti‐inflammatory and osteogenic effects of transcutaneous electrical nerve stimulation in knee osteoarthritis rats via the regulation of the intestinal microbiota

Animal Models and Experimental Medicine, EarlyView.
Transcutaneous electrical nerve stimulation (TENS) improved knee osteoarthritis (KOA) in rats by regulating interleukin‐1β (IL‐1β), IL‐6, and IL‐8 expressions and the bone morphogenetic protein 2 (BMP‐2)/transforming growth factor β (TGF‐β) signaling pathway.
Yan Sun, Tong Ma, Ran Chen, Lan Shen, Xun Tang, Zhiqiang Shen, Hongbin Zhao   +6 more
wiley   +1 more source

Insights into osteoarthritis development from single-cell RNA sequencing of subchondral bone

RMD Open, 2022
Ping Shen, Max Löhning
doaj   +1 more source

Osteoarthritis patients exhibit an autonomic dysfunction with indirect sympathetic dominance

Journal of Translational Medicine
Background Osteoarthritis (OA) is a chronic degenerative joint disease causing limited mobility and pain, with no curative treatment available. Recent in vivo studies suggested autonomic alterations during OA progression in patients, yet clinical ...
Rebecca Sohn, Tina Assar, Isabelle Kaufhold, Marco Brenneis, Sebastian Braun, Marius Junker, Frank Zaucke, Georg Pongratz, Zsuzsa Jenei-Lanzl   +8 more
doaj   +1 more source