Results 221 to 230 of about 497,266 (304)

Targeting CKIP‐1 for Disease Therapy: Cellular Functions, Molecular Networks, and Clinical Potential

Cell Proliferation, EarlyView.
CKIP‐1, as a scaffold protein with special structural domains, treats related diseases through multiple emerging targeted technologies.
Xin Huang, Shijie Lv, Lejia Li, Jirong Xie, Zhengguo Cao   +4 more
wiley   +1 more source

EZH2 coordinates inflammatory and pain-associated pathways across joint compartments in osteoarthritis. [PDF]

Mol Biomed
Brochard S, Vanlaeys A, Taieb M, Richard I, Aury-Landas J, Bernay B, Pontin J, Seillier C, Bon N, Picart B, Pecqueur C, Toutirais O, Vinatier C, Guicheux J, Maubert E, Agin V, Boumediene K, Bauge C.   +17 more
europepmc   +1 more source

Purpurin Alleviates Meniscal Senescence and Osteoarthritis by Blocking the Non‐Metabolic Function of Hexokinase 2

Cell Proliferation, EarlyView.
HK2 is upregulated in osteoarthritis and accelerates disease progression via a glycolysis‐independent non‐metabolic mechanism. It recruits PRKN to degrade MYH10, reducing COL1A1 mRNA stability and inducing senescence. Purpurin disrupts this pathogenic pathway with therapeutic potential.
Zhencan Lin, Ming Li, Wei Li, Tianfa Xu, Zongrui Jiang, Yanlin Zhong, Aishan He, Xiaoyi Zhao, Dianbo Long, Yan Kang   +9 more
wiley   +1 more source

Neuropsychiatric Outcomes Associated With GLP‐1 Receptor Agonist Use in Medicare Beneficiaries With Type 2 Diabetes: Variation by Treatment Pattern and Obesity Status

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Glucagon‐like peptide‐1 (GLP‐1) receptors are expressed in brain regions governing mood, reward and stress, yet the neuropsychiatric effects of GLP‐1 receptor agonist (GLP‐1 RA) therapy remain poorly characterized. We estimated associations between GLP‐1 RA use and neuropsychiatric disorders and variation by obesity status and treatment ...
Seo Hyon Baik, Fitsum Baye, Haotian Xian, Kin Wah Fung, Clement J. McDonald   +4 more
wiley   +1 more source

Omics Studies in Osteoarthritis: A Review of Molecular Mechanisms and Candidate Molecules. [PDF]

Biomolecules
Sun Y, Xiao Q, Jin M, Liu G, Zhang Q, Wei X.   +5 more
europepmc   +1 more source

Cumulative effects of lifelong systemic excess growth hormone on postcranial skeletal morphology in adult mice

Journal of Anatomy, EarlyView.
Our μCT‐based pilot study reveals size and shape disparity in the adult postcranial skeleton of growth‐hormone model (bGH) mice relative to wild‐type mice. bGH mice have larger and more sexually dimorphic bones, with a systemic radiodensity increase in bony sesamoids and associated, but typically uncalcified, soft tissues.
Joseph R. Groenke, Huanhuan Liu, Grace Lach, Abhishek Wajpe, Darlene Berryman, John J. Kopchick, Shouan Zhu, Patrick M. O'Connor   +7 more
wiley   +1 more source

Severity‐Graded MRI‐Detected TMJ Effusion Is Associated With Pain and Dysfunction in Temporomandibular Disorder Patients

Journal of Oral Rehabilitation, EarlyView.
In patients with TMJ arthralgia, MRI‐detected joint effusion was graded from Grade 0 (no effusion) to Grade 2 (moderate‐to‐severe effusion) using T2‐weighted and proton density‐weighted images. Increasing effusion severity was associated with greater pain intensity and mandibular dysfunction.
Yeon‐Hee Lee, Seong‐Woo Jang, Seonggwang Jeon, Q‐Schick Auh, Yung‐Kyun Noh   +4 more
wiley   +1 more source

Towards a consensus definition of "refractory osteoarthritis". A systematic review. [PDF]

Ther Adv Musculoskelet Dis
Migliore A, De Lucia O, Heusdens C, Alrahoomi A, Benazzo F, Chevalier X, Diracoglu D, Krochmalski M, Maillet B, Neri T, Rodrigo JL, Tobolski O, Henrotin Y.   +12 more
europepmc   +1 more source

Tooth Wear Severity and Temporomandibular Joint Degenerative Findings on Cone‐Beam Computed Tomography: A Cross‐Sectional Study in Adults

Journal of Oral Rehabilitation, EarlyView.
In 80 adults with TMD symptoms (160 joints), tooth wear was scored clinically and TMJ degeneration was assessed on CBCT. Adjusted analyses showed no association with osteophytes, erosion, subchondral cysts, or definite osteoarthritis, indicating that tooth wear alone does not predict TMJ degeneration.
Gizem Altundal, Ceyda Deniz Özdemir, Ece Zorlu, Fatma Yüce, Sibel Biren   +4 more
wiley   +1 more source

The Anti-Osteoarthritis Effect of Medicinal and Edible Homologous Bioactive Components and Chinese Medicinal and Health Food Varieties. [PDF]

Nutrients
Wang H, Zhang G, Zheng S, Sun Y.
europepmc   +1 more source