Hypertrophic osteoarthropathy associated with lung cancer: Possible links among hypoxia‐inducible factor‐1α, vascular endothelial growth factor, and hypervascularization [PDF]
Thoracic Cancer, 2023 Hypertrophic osteoarthropathy (HOA) is a paraneoplastic syndrome, the exact pathogenesis of which remains to be elucidated. The case of a 69‐year‐old man who developed intractably painful HOA secondary to lung cancer is presented.
Ryuta Tagawa +12 more
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A Case Report of Pulmonary Hypertrophic Osteoarthropathy Secondary to Pulmonary Carcinoma [PDF]
Chinese Journal of Lung Cancer, 2010 患者,男,54岁,因“指(趾)末端无痛性、进行 性增粗3年,膝、踝关节疼痛伴活动障碍2年”入住天津医 科大学总医院。患者曾先后就诊于内分泌科和血液科, 未明确诊断。自发病以来,无咳嗽、咳痰、咯血、胸痛 等症状。既往体健,吸烟40年,20支/天。其母死于肺 癌。入院查体:甲床无紫绀;双肺呼吸音清,未闻及啰 音;心音有力,律齐,未闻及杂音;明显杵状指(趾) 伴周围皮肤红肿、发亮,皮温稍高,无触痛,呈对称分 布(图1);双侧膝、踝关节轻度肿胀,轻压痛,浮髌 试验阴性。实验室检查:血、尿、便常规、凝血功能、 肝肾功能、电解质以及免疫全项(抗核抗体、类风湿因 子和抗中性粒细胞胞浆抗体)等均正常。双膝X线示: 双侧股骨下端、胫骨上端及腓骨近端可见对称性骨膜增 生,考虑双膝关节肺性肥大性骨关节病(图2)。全身骨 ...
Linjuan LIAN, Diansheng ZHONG, Song WU
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Hypertrophic Osteoarthropathy: A Secondary Manifestation of Malignant Melanoma [PDF]
Case Reports in Rheumatology, 2021 Background. Hypertrophic osteoarthropathy (HOA) is a rare finding in the setting of metastatic melanoma. A majority of cases of secondary HOA involve lung malignancies.
Shiva Malaty, Aditya Gupta
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HYPERTROPHIC OSTEOARTHROPATHY IN A PATIENT WITH HETEROZYGOUS MUTATION IN THE SLCO2A1 GENE: A CASE REPORT [PDF]
Central Asian Journal of Medical Hypotheses and Ethics, 2023 Hypertrophic osteoarthropathy (HOA) is a condition characterized by aberrant skin and osseous tissue proliferation in the distal extremities. Mutations in the 15-hydroxyprostaglandin dehydrogenase gene (HPGD) and the soluble carrier organic anion carrier
Ilke Coskun Benlidayi +2 more
doaj +3 more sources
Primary hypertrophic osteoarthropathy – a rare cause of pain and arthritis in children. Description of 5 cases [PDF]
Central European Journal of Immunology, 2022 Primary hypertrophic osteoarthropathy (PHOA) is a very rare disease. The typical triad of symptoms, i.e. digital clubbing, periosteal bone formation with bone and joint deformities and skin hypertrophy, may be accompanied by other specific conditions. In
Joanna Wójtowicz +3 more
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Pachydermoperiostosis Mimicking Inflammatory Arthritis: Case Description and Narrative Review [PDF]
Rheumato, 2023 Pachydermoperiostosis (PDP), also called primary hypertrophic osteoarthropathy (HOA), is a rare genetic disease with typical thickening of the skin (pachydermia) and rheumatic manifestations, with clubbing of the fingers and toes and periostosis of the ...
AKM Kamruzzaman +7 more
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Hypertrophy of the feet and ankles presenting in primary hypertrophic osteoarthropathy or pachydermoperiostosis: a case report [PDF]
Journal of Medical Case Reports, 2012 Introduction Pachydermoperiostosis or primary hypertrophic osteoathropathy is a rare genetic disease with autosomal transmission. This disorder, which affects both bones and skin, is characterized by the association of dermatologic changes (pachydermia ...
Akrout Rim +5 more
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Hypertrophic pulmonary osteoarthropathy secondary to pulmonary malignancy: A case report
Journal of Orthopaedic Reports, 2022 Background: Hypertrophic pulmonary osteoarthropathy is a rare type of paraneoplastic rheumatic manifestation which classically presents with bilateral, symmetrical periostitis of long bones, digital clubbing, and non-inflammatory arthritic pain and ...
Steven R. Cooperman, Raffi Salibian
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Touraine-Solente-Gole syndrome: pathogenic variant in SLCO2A1 presented with polyarthralgia and digital clubbing [PDF]
Pediatric Rheumatology Online Journal, 2023 Background Primary Hypertrophic Osteoarthropathy (PHO), also known as Touraine-Solente-Gole Syndrome, is a rare, multisystemic autosomal recessive disorder caused by pathogenic variants in the 15-hydroxyprostaglandin dehydrogenase (HPGD) or Solute ...
Rafaela Nicolau +7 more
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Secondary hypertrophic osteoarthropathy an unusual cause of arthritis in childhood [PDF]
Arthritis & Rheumatism, 1976 Although an uncommon occurrence in childhood, hypertrophic osteoarthropathy secondary to tumors—most commonly to osteogenic sarcoma with pulmonary metastasis—may cause severe joint pain and swelling.
Adler +14 more
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