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Osteoclast–osteoblast communication
Archives of Biochemistry and Biophysics, 2008Cells in osteoclast and osteoblast lineages communicate with each other through cell-cell contact, diffusible paracrine factors and cell-bone matrix interaction. Osteoclast-osteoblast communication occurs in a basic multicellular unit (BMU) at the initiation, transition and termination phases of bone remodeling.
Koichi, Matsuo, Naoko, Irie
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Pinacidil stimulates osteoblast function in osteoblastic MC3T3-E1 cells
Immunopharmacology and Immunotoxicology, 2013This study examined the effect of pinacidil, a nonselective adenosine triphosphate-sensitive potassium channel opener, on the function of osteoblastic MC3T3-E1 cells. Pinacidil caused a significant elevation of collagen synthesis, alkaline phosphatase activity, osteocalcin synthesis and mineralization in the cells (p
Kwang Sik, Suh +2 more
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Regulation of Osteoblast Differentiation by Slit2 in Osteoblastic Cells
Cells Tissues Organs, 2008<i>Background/Aims:</i> There is an urgent need to identify the molecular factors involved in osteoblast proliferation and differentiation in order to improve bone formation and treat bone disease. Recent studies demonstrate that many ‘axon guidance’ molecules play important roles in the development and remodeling of bone through their ...
Hongli, Sun +3 more
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2011
This chapter describes the isolation, culture and staining of primary osteoblasts from the calvaria and long bones of neonatal rats. The key advantages of this assay are that it allows direct measurement of bone matrix deposition and mineralisation, as well as yielding good quantities of osteoblasts at defined stages of differentiation for molecular ...
Isabel R, Orriss +2 more
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This chapter describes the isolation, culture and staining of primary osteoblasts from the calvaria and long bones of neonatal rats. The key advantages of this assay are that it allows direct measurement of bone matrix deposition and mineralisation, as well as yielding good quantities of osteoblasts at defined stages of differentiation for molecular ...
Isabel R, Orriss +2 more
openaire +2 more sources
Regulation of Osteoblast Activity and the Osteoblast-Osteocyte Transformation
1982According to currently held concepts of bone formation (Table 1), osteoblasts develop from mitotically competent marrow stromal cells by a process of non-mitotic differentiation (modulation) (1,2). Osteoblasts are attracted to the bone surfaces, and are activated to elaborate lamellae of collagen-rich organic matrix (osteoid) which is subsequently ...
W A, Peck, L, Rifas
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2013
Bone formation takes place throughout life in order to support growth, mechanical forces, bone turnover to meet metabolic needs, and the reparative process. The requirement for continuous renewal of bone through the remodeling process necessitates recruitment, proliferation, and differentiation of osteoblast-lineage cells. A contributing factor to bone
van Leeuwen, Johannes P.T.M. +4 more
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Bone formation takes place throughout life in order to support growth, mechanical forces, bone turnover to meet metabolic needs, and the reparative process. The requirement for continuous renewal of bone through the remodeling process necessitates recruitment, proliferation, and differentiation of osteoblast-lineage cells. A contributing factor to bone
van Leeuwen, Johannes P.T.M. +4 more
openaire +1 more source