Results 271 to 280 of about 122,840 (307)

Inorganic Polyphosphate Induces Osteoblastic Differentiation

Journal of Dental Research, 2010
Inorganic polyphosphate [Poly(P)] is especially prevalent in osteoblasts. We tested the hypothesis that Poly(P) stimulates osteoblastic differentiation and polyphosphate metabolism for bone formation. The osteoblast-like cell line, MC 3T3-E1, was cultured with Poly(P), and gene expression was evaluated by real-time reverse-transcription polymerase ...
Y, Usui, T, Uematsu, T, Uchihashi, M, Takahashi, M, Takahashi, M, Ishizuka, R, Doto, H, Tanaka, Y, Komazaki, M, Osawa, K, Yamada, M, Yamaoka, K, Furusawa   +12 more
openaire   +2 more sources

Proteomic profiling of differentiating osteoblasts

Expert Review of Proteomics, 2006
The major event that triggers osteogenesis is the transition of mesenchymal stem cells into bone-forming, differentiating osteoblast cells. Osteoblast differentiation is the primary event of bone formation, exemplified by the synthesis, deposition and mineralization of extracellular matrix. Osteoblast differentiation is controlled tightly by sequential
Josip, Blonder, Zhen, Xiao, Timothy D, Veenstra   +2 more
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Regulation of Osteoblast Differentiation by Slit2 in Osteoblastic Cells

Cells Tissues Organs, 2008
<i>Background/Aims:</i> There is an urgent need to identify the molecular factors involved in osteoblast proliferation and differentiation in order to improve bone formation and treat bone disease. Recent studies demonstrate that many ‘axon guidance’ molecules play important roles in the development and remodeling of bone through their ...
Hongli, Sun, Kerong, Dai, Tingting, Tang, Xiaoling, Zhang   +3 more
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Osteoblastic differentiation.

Ciba Foundation symposium, 1989
The fully differentiated osteoblast may be easily recognized in bone tissue. Its cuboidal shape, its position directly opposed to the bone surface and its capacity to produce calcified bone matrix are characteristic. Three other differentiation stages are also reasonably well defined--the preosteoblast, the osteocyte and the lining cell.
P J, Nijweide, A, van der Plas, A A, Olthof   +2 more
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Osteoblast differentiation during orthodontic tooth movement

Orthodontics & Craniofacial Research, 2019
AbstractObjectivesTo analyse the expression of osteoblast differentiation markers and osteoclast activity in the periodontal ligament (PDL) following 2, 4 and 7 days of orthodontic tooth movement (OTM) in an animal model.Setting and Sample PopulationEighteen C57BL/6 wild‐type mice.Material and MethodsFor the OTM model, orthodontic force was applied to ...
Robert Holland, Carol Bain, Achint Utreja   +2 more
openaire   +2 more sources

Collagen Cross-Linking Influences Osteoblastic Differentiation

Calcified Tissue International, 2008
Osteoblasts synthesize collagen matrix, which itself regulates the differentiation of precursor cells into mature osteoblasts. They express lysyl oxidase (LOX), which is involved in the collagen cross-linking process. Lathyrogens, like ss-aminopropionitrile (ssAPN), inhibit the formation of a stable matrix.
C, Turecek, N, Fratzl-Zelman, M, Rumpler, B, Buchinger, S, Spitzer, R, Zoehrer, E, Durchschlag, K, Klaushofer, E P, Paschalis, F, Varga   +9 more
openaire   +2 more sources

Transcriptional profiling of human osteoblast differentiation

Journal of Cellular Biochemistry, 2003
AbstractOsteoblast differentiation is a key aspect of bone formation and remodeling. To further our understanding of the differentiation process, we have developed a collection of conditionally immortalized adult human osteoblast cell lines representing discrete stages of differentiation.
J, Billiard, R A, Moran, M Z, Whitley, M, Chatterjee-Kishore, K, Gillis, E L, Brown, B S, Komm, P V N, Bodine   +7 more
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Osteoblasts: Differentiation and Function

1993
Cells of the osteoblast lineage occupy a central position in bone metabolism. The formation of a structurally sound skeleton, with its strength and integrity conserved by constant remodeling, and the formation as well as activation of the major bone-resorbing cell, the osteoclast, are the result of direct and indirect influences of osteoblasts.
T. J. Martin, D. M. Findlay, J. K. Heath, K. W. Ng   +3 more
openaire   +1 more source

Differentiation of Osteoblasts on Pectin-Coated Titanium

Biomacromolecules, 2008
The gold standard for implant metals is titanium, and coatings such as collagen-I, RGD-peptide, chondroitin sulfate, and calcium phosphate have been used to modify its biocompatibility. We investigated how titanium coated with pectins, adaptable bioactive plant polysaccharides with anti-inflammatory effects, supports osteoblast differentiation.
Kokkonen, H., Cassinelli, C., Verhoef, R., Morra, M., Schols, H.A., Tuukkanen, J.   +5 more
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Osteosarcoma and Osteoblastic Differentiation

Clinical Orthopaedics and Related Research, 2007
In addition to changes in cellular pathways, loss of differentiation is a notable feature of osteosarcoma. We hypothesized that blocks to normal differentiation may be a common feature of osteosarcoma, and may be one of many critical events that occur during oncogenesis in osteosarcoma.
Rex C, Haydon, Hue H, Luu, Tong-Chuan, He   +2 more
openaire   +2 more sources