Results 41 to 50 of about 7,611 (212)

Mastication‐Induced Electrical Stimulation Activates Prg4+ Chondroprogenitors for Osteoarthritis Therapy

Advanced Science, EarlyView.
This study presents a ″trash‐to‐treasure″ strategy that converts harmful joint overloads into beneficial electrical cues. The biodegradable MagPie, by providing piezoelectrical stimulation and releasing Mg2+ during mastication, exerts synergistic pro‐regenerative and anti‐inflammatory effects on Prg4+ cells via the ECM‐mediated FAK‐PI3K‐Akt axis ...
Shi‐Yang Feng, Jing‐Rong Cheng, Yu Qin, Jie Lei, Chen‐Chen Gao, Hong‐Ying Fu, Li‐Ping Wu, Thanh D. Nguyen, Xu‐Liang Deng, Kai‐Yuan Fu, Yang Liu   +10 more
wiley   +1 more source

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Cell‐free osteochondral scaffolds provide a substantial clinical benefit in the treatment of osteochondral defects at a minimum follow‐up of 5 years

Journal of Experimental Orthopaedics, 2021
Purpose The treatment of osteochondral lesions is challenging and no consensus has been established about the best option for restoring both cartilage and subchondral bone.
Martina Ricci, Daniele Tradati, Alessio Maione, Francesco Mattia Uboldi, Eva Usellini, Massimo Berruto   +5 more
doaj   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Excellent Outcomes and High Rates of Return to Duty but a 10% Chance of Tear Progression Are Seen Following Arthroscopic Debridement Alongside Adjunctive Procedures for Articular‐Sided, Partial‐Thickness Supraspinatus Tears (Ellman Grade I) in Active‐Duty Service Members Younger Than 50 Years

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To evaluate clinical outcomes and return‐to‐duty rates in active‐duty service members younger than 50 years after arthroscopic debridement of Ellman grade I, articular‐sided partial‐thickness rotator cuff tears (PT‐RCTs) of the supraspinatus.
Brian Skura, Ian S. Rice, Alexis B. Sandler, Samuel Howard, Richy Charls, John Tyler, John P. Scanaliato, Ron Gilat, Nata Parnes   +8 more
wiley   +1 more source

Diagnosis and Treatment of Osteochondritis Dissecans of the Knee

Orthopaedic Journal of Sports Medicine
Osteochondritis dissecans (OCD) of the knee is a common osteochondral lesion in young generation, in which the subchondral bone eventually separates along with its superficial cartilage layer.
Nobuo Adachi
doaj   +1 more source

Osteochondral autograft transfer (mosaicplasty) for treatment of patients with osteochondral lesions of talus

Chinese Journal of Traumatology, 2020
Purpose: Osteochondral lesion of talus (OLT) is one of the common causes of ankle pain. This disorder is common in young athletes after ankle injury. There are various therapeutic options. One of the options is mosaic plasticizer.
Amir Sabaghzadeh, Fateme Mirzaee, Heydar Shahriari Rad, Fateme Bahramian, Ardeshir Alidousti, Hamidreza Aslani   +5 more
doaj   +1 more source

The Presence of Chondral Pathology Is Not Associated With an Increase in Meniscal Root Retear, Reoperation, or Subsequent Total Knee Arthroplasty Rates

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To identify whether chondral pathology is associated with an increase in failure rates of isolated meniscal root repairs. Methods We retrospectively reviewed meniscus repairs from 2012 to 2022 at the author's institution. Nonroot repairs and cases with total or same compartment meniscectomy, cartilage restoration, osteotomy, or other concurrent
Matthew D. Benson, Richard J. VanTienderen, Austin C. Benson, Benjamin D. Packard, Steven M. Leary, Kyle R. Duchman, Brian R. Wolf, Robert W. Westermann   +7 more
wiley   +1 more source

Arthroscopic Bone Graft Remplissage Using Flexible Bone Allograft for Treatment of Hill‐Sachs Lesions in Anterior Shoulder Instability

Arthroscopy Techniques, EarlyView.
Hill‐Sachs lesions are defects in the posterior humeral head from anterior glenoid impaction during dislocation. Left untreated, they can contribute to failure after arthroscopic Bankart repair. Arthroscopic remplissage, involving capsulotenodesis of the posterior capsule and infraspinatus tendon, is the most frequently performed approach to address ...
Sailesh V. Tummala, Romir P. Parmar, Eugenia A. Lin, John M. Tokish   +3 more
wiley   +1 more source

Osteochondral Autograft and Allograft for Osteochondral Lesions of the Talus

Foot & Ankle Orthopaedics, 2018
Category: Ankle Introduction/Purpose: Cartilage lesions of the talus are a challenging clinical pathology for orthopaedic surgeons. To date, the treatment guidelines for these lesions have been based on both low quality and low levels of evidence ...

doaj   +1 more source