Results 1 to 10 of about 24,690 (186)

YTHDF1 transcriptionally activated by TCF4 suppresses osteoblast ferroptosis in titanium nanoparticle-induced osteolysis by accelerating GPX4 and SLC7A11 translation [PDF]

Journal of Nanobiotechnology
Background Aseptic loosening and periprosthetic osteolysis driven by wear particles are major causes of total joint arthroplasty (TJA) failure. Investigating the upstream mechanisms of osteoblast ferroptosis in periprosthetic osteolysis is essential for ...
Da Zhong, Wenqing Xie, Zhan Liao, Hua Liu, Lemei Zhu, Fawei Gao, Xi Li, Zhen Yin, Ganzhe Xu, Peng Chen, Jian Tian, Long Wang, Ke Yin, Kunli Chen, Chenggong Wang   +14 more
doaj   +2 more sources

Asymptomatic osteolysis as a risk factor for cardiovascular disease after total hip arthroplasty: A retrospective cohort study. [PDF]

PLoS ONE
Background and purposeA clinical problem in total hip arthroplasty (THA) is periprosthetic osteolysis/aseptic loosening. There is a possible association between periprosthetic osteolysis and higher risk of cardiovascular disease (CVD).
Agata Rysinska, Sara Aspberg, Thomas Eisler, Michael Axenhus, Nils P Hailer, Daniel Hallman, Evaldas Laurencikas, Max Gordon, Olof Sköldenberg   +8 more
doaj   +2 more sources

Volume and Distribution of Periprosthetic Bone Cysts in the Distal Tibia and Talus before Early Revision of Total Ankle Arthroplasty

Applied Sciences, 2021
Periprosthetic osteolysis is a common complication following total ankle arthroplasty (TAA). However, understanding of osteolysis volume and distribution is still evolving, undermining efforts to reduce the incidence of osteolysis via bone remodeling. We
Seoyeong Kim, Jinju Jang, Jae-Hyuk Choi, Hai-Mi Yang, Heoung-Jae Chun, Gun-Woo Lee, Keun-Bae Lee, Dohyung Lim   +7 more
doaj   +1 more source

SPHK Inhibitors and Zoledronic Acid Suppress Osteoclastogenesis and Wear Particle-Induced Osteolysis

Frontiers in Pharmacology, 2022
Background: Inflammatory osteolysis induced by wear particles is the major cause of prosthetic loosening after artificial joint replacement, and its prevention and treatment are difficult worldwide.
Minghui Gu, Minghui Gu, Baiqi Pan, Baiqi Pan, Weishen Chen, Weishen Chen, Hai Xu, Xiaoyu Wu, Xiaoyu Wu, Xuantao Hu, Xuantao Hu, Linli Zheng, Linli Zheng, Yongyu Ye, Qing Meng, Qing Meng, Guoyan Xian, Guoyan Xian, Guoyan Xian, Ziji Zhang, Ziji Zhang, Puyi Sheng, Puyi Sheng   +22 more
doaj   +1 more source

Desferrioxamine alleviates UHMWPE particle-induced osteoclastic osteolysis by inhibiting caspase-1-dependent pyroptosis in osteocytes

Journal of Biological Engineering, 2022
Background Cell death and inflammation are the two important triggers of wear particle-induced osteolysis. Particles, including cobalt-chromium-molybdenum and tricalcium phosphate, have been reported to induce pyroptosis in macrophages and osteocytes ...
Shenli Zhao, Chen Ge, Yao Li, Leilei Chang, Zhou Dan, Yihui Tu, Lianfu Deng, Hui Kang, Changwei Li   +8 more
doaj   +1 more source

Selenomethionine against titanium particle-induced osteolysis by regulating the ROS-dependent NLRP3 inflammasome activation via the β-catenin signaling pathway

Frontiers in Immunology, 2023
Wear debris-induced osteolysis, especially titanium (Ti) particles-induced osteolysis, is the most common cause of arthroplasty failure with no effective therapy.
Ruixuan Yu, Yongjian Yuan, Zhicheng Liu, Zhicheng Liu, Long Liu, Zhaoning Xu, Yunpeng Zhao, Chunwang Jia, Pengfei Zhang, Hang Li, Yuhao Liu, Yi Wang, Yi Wang, Weiwei Li, Lin Nie, Xuecheng Sun, Yuhua Li, Ben Liu, Haichun Liu   +18 more
doaj   +1 more source

Enteropathogenic Escherichia coli Mediates CoCrMo Particle-Induced Peri-Implant Osteolysis by Increasing Peripheral 5-HT

Frontiers in Cellular and Infection Microbiology, 2022
The human gut microbiota has been proven to have great effects on the regulation of bone health. However, the association between gut microbiota and particle-induced osteolysis, which is the primary cause of aseptic loosening, is still unknown.
Kaiwen Xue, Ruijie Tao, Qi Wu, Lei Zhang, Zhongyang Sun, Xing Yu, Jia Meng, Nirong Bao, Jianning Zhao   +8 more
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Acro-osteolysis

European Journal of Rheumatology, 2019
Abstract Cite this article as: Thomas J, Jose J. Acro-osteolysis. Eur J Rheumatol 2019; 6(2): 109-10.
Joe Thomas, Jewel Jose
openaire   +4 more sources

Interleukin 11 (IL-11): Role(s) in Breast Cancer Bone Metastases

Biomedicines, 2021
Bone metastases represent the main problem related to the progression of breast cancer, as they are the main cause of death for these patients. Unfortunately, to date, bone metastases are incurable and represent the main challenge for the researcher ...
Paola Maroni, Paola Bendinelli, Anita Ferraretto, Giovanni Lombardi   +3 more
doaj   +1 more source

Celastrol Attenuates RANKL-Induced Osteoclastogenesis in vitro and Reduces Titanium Particle-Induced Osteolysis and Ovariectomy-Induced Bone Loss in vivo

Frontiers in Pharmacology, 2021
Excessive bone resorption by osteoclasts contributes significantly to osteoclast-related diseases such as periprosthetic osteolysis and osteoporosis. Osteolysis in a titanium particle-induced calvarial model and bone loss in an ovariectomized mice model ...
Qiang Xu, Guiping Chen, Guiping Chen, Huaen Xu, Guoming Xia, Meisong Zhu, Haibo Zhan, Bin Zhang, Min Dai, Hongxian Fan, Hongxian Fan, Xuqiang Liu   +11 more
doaj   +1 more source