Results 1 to 10 of about 15,355 (222)

Severe Metallosis-Induced Osteolysis and Polyethylene Liner Dissociation as a Cause of Total Knee Replacement Failure [PDF]

Journal of Orthopaedic Case Reports
Introduction: Metallosis is a rare but recognized complication following total knee replacement (TKR). It is characterized by metallic particle deposition within periprosthetic tissue, triggering chronic inflammation, progressive osteolysis, and implant ...
Jipin Gopi, Abdulla Harafan, Shisham Hashim Roshan, M Aswin Ravindran, Adarsh, N R Fijad   +5 more
doaj   +2 more sources

YTHDF1 transcriptionally activated by TCF4 suppresses osteoblast ferroptosis in titanium nanoparticle-induced osteolysis by accelerating GPX4 and SLC7A11 translation [PDF]

Journal of Nanobiotechnology
Background Aseptic loosening and periprosthetic osteolysis driven by wear particles are major causes of total joint arthroplasty (TJA) failure. Investigating the upstream mechanisms of osteoblast ferroptosis in periprosthetic osteolysis is essential for ...
Da Zhong, Wenqing Xie, Zhan Liao, Hua Liu, Lemei Zhu, Fawei Gao, Xi Li, Zhen Yin, Ganzhe Xu, Peng Chen, Jian Tian, Long Wang, Ke Yin, Kunli Chen, Chenggong Wang   +14 more
doaj   +2 more sources

Clinical features and computed tomography findings of retrobulbar disease in cats [PDF]

Frontiers in Veterinary Science
The objective of this study was to describe the clinical features and computed tomography (CT) findings of cats affected with retrobulbar disease. The medical records of 37 client-owned cats diagnosed with retrobulbar disease between the years 2009–2024 ...
Kristen Hasegawa, Anna Vincek, Janny V. Evenhuis, Stephanie Goldschmidt, Maria Soltero-Rivera, Natalia Vapniarsky, Kathryn Good, Claudio J. Gutierrez, Boaz Arzi   +8 more
doaj   +2 more sources

SENP6-mediated desumoylation of SMAD5 regulates osteogenic fate in periodontal ligament stem cells [PDF]

European Journal of Medical Research
Background Periodontal ligament stem cells (PDLSCs) are essential for periodontal tissue regeneration, but their osteogenic differentiation is significantly impaired in the inflammatory microenvironment of periodontitis.
Hui Jin, Chengmin Liu, Wenchao Wang, Huawei Xie, Bo Ji, Wenjia Wei, Xiaofeng Wang   +6 more
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Prosthetic Loosening in a Total Hip Arthroplasty Patient After Breast Cancer Chemotherapy and Hormonal Therapy: A Case Report [PDF]

Drug, Healthcare and Patient Safety
Jiemin Li,1,* Shixun Li,2,* Changchuan Li,2 Zhong Chen,2 Yue Ding2 1Department of Nurse Administration, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 2Department of Orthopaedic ...
Li J, Li S, Li C, Chen Z, Ding Y
doaj   +1 more source

Pathogenesis, Evaluation, and Management of Osteolysis After Total Shoulder Arthroplasty [PDF]

Clinics in Shoulder and Elbow, 2022
Radiographic osteolysis after total shoulder arthroplasty (TSA) remains a challenging clinical entity, as it may not initially manifest clinically apparent symptoms but can lead to clinically important complications, such as aseptic loosening. A thorough
Kyle N. Kunze, Laura M. Krivicich, Christopher Brusalis, Samuel A. Taylor, Lawrence V. Gulotta, Joshua S. Dines, Michael C. Fu   +6 more
doaj   +1 more source

Selenomethionine against titanium particle-induced osteolysis by regulating the ROS-dependent NLRP3 inflammasome activation via the β-catenin signaling pathway

Frontiers in Immunology, 2023
Wear debris-induced osteolysis, especially titanium (Ti) particles-induced osteolysis, is the most common cause of arthroplasty failure with no effective therapy.
Ruixuan Yu, Yongjian Yuan, Zhicheng Liu, Zhicheng Liu, Long Liu, Zhaoning Xu, Yunpeng Zhao, Chunwang Jia, Pengfei Zhang, Hang Li, Yuhao Liu, Yi Wang, Yi Wang, Weiwei Li, Lin Nie, Xuecheng Sun, Yuhua Li, Ben Liu, Haichun Liu   +18 more
doaj   +1 more source

Chemical Pleurodesis Using Extract in Gorham Disease Complicated with Chylothorax [PDF]

Acute and Critical Care, 2018
Gorham disease, also known as massive osteolysis, is characterized by unregulated proliferation of lymphatic or vascular capillaries within bone, resulting in destruction and replacement with angiomatous tissue.
Suk Ju Cho, Su Wan Kim
doaj   +1 more source

Harmine Alleviates Titanium Particle-Induced Inflammatory Bone Destruction by Immunomodulatory Effect on the Macrophage Polarization and Subsequent Osteogenic Differentiation

Frontiers in Immunology, 2021
Peri-prosthetic osteolysis (PPO) and following aseptic loosening are regarded as the prime reasons for implant failure after joint replacement. Increasing evidence indicated that wear-debris-irritated inflammatory response and macrophage polarization ...
Liangliang Wang, Qing Wang, Wei Wang, Gaoran Ge, Nanwei Xu, Dong Zheng, Shijie Jiang, Gongyin Zhao, Yaozeng Xu, Yuji Wang, Yuji Wang, Yuji Wang, Ruixia Zhu, Dechun Geng   +13 more
doaj   +1 more source

Prednisone prevents particle induced bone loss in the calvaria mouse model

Heliyon, 2021
Introduction: Glucocorticoids are essential in the treatment of many chronic inflammatory and malignant diseases but are known to have detrimental effects on bone.
Michael M. Schündeln, Jakob Höppner, Felix L. Meyer, Wiebke Schmuck, Max D. Kauther, Gero Hilken, Bodo Levkau, Martina Rauner, Corinna Grasemann   +8 more
doaj   +1 more source