Results 21 to 30 of about 15,355 (222)

Inflammasomes in Alveolar Bone Loss

Frontiers in Immunology, 2021
Bone remodeling is tightly controlled by osteoclast-mediated bone resorption and osteoblast-mediated bone formation. Fine tuning of the osteoclast–osteoblast balance results in strict synchronization of bone resorption and formation, which maintains ...
Yang Li, Junqi Ling, Junqi Ling, Qianzhou Jiang   +3 more
doaj   +1 more source

Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma. [PDF]

, 2014
Ewing sarcoma is the second-most-common bone cancer in children. Driven by an oncogenic chromosomal translocation that results in the expression of an aberrant transcription factor, EWS/FLI, the disease is typically aggressive and micrometastatic upon ...
Beckerle, Mary C, Chaturvedi, Aashi, Grossmann, Allie H, Hoffman, Laura M, Jensen, Christopher C, Lessnick, Stephen L, Lin, Yi-Chun, Randall, R Lor, Welm, Alana L   +8 more
core   +1 more source

Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone

eLife, 2023
Colony-stimulating factor 1 (Csf1) is an essential growth factor for osteoclast progenitors and an important regulator for bone resorption. It remains elusive which mesenchymal cells synthesize Csf1 to stimulate osteoclastogenesis. We recently identified
Leilei Zhong, Jiawei Lu, Jiankang Fang, Lutian Yao, Wei Yu, Tao Gui, Michael Duffy, Nicholas Holdreith, Catherine A Bautista, Xiaobin Huang, Shovik Bandyopadhyay, Kai Tan, Chider Chen, Yongwon Choi, Jean X Jiang, Shuying Yang, Wei Tong, Nathanial Dyment, Ling Qin   +18 more
doaj   +1 more source

Contemporary indications for first-time revision surgery after primary cementless total hip arthroplasty with emphasis on early failures

Journal of Orthopaedic Surgery and Research, 2021
Background To clarify contemporary indications for first-time revision surgery after primary cementless total hip arthroplasty (THA) for addressing potential issues with cementless THA.
Goro Motomura, Satoshi Hamai, Satoshi Ikemura, Masanori Fujii, Shinya Kawahara, Soichiro Yoshino, Yasuharu Nakashima   +6 more
doaj   +1 more source

Solitary plasmacytoma of the rib: A rare tumor to keep in mind: Case report

Radiology Case Reports, 2023
Around 5% of plasma cell neoplasias are solitary plasmacytomas, a tumor that is fairly rare. The presence of a localized tumor composed of monoclonal plasma cells that are the same as those found in multiple myeloma and the absence of symptoms that would
Khadija Laasri, MD, Abir El hamzi, MD, Mohamed Ismail Halfi, MD, Mohammed Allaoui, PhD, Jamal El fenni, PhD, Issam En nafaa, PhD, Mohamed Lahkim, PhD   +6 more
doaj   +1 more source

Vanishing (Disappearing) Bone Disease in children: a review [PDF]

, 2011
Vanishing bone disease is a very rare, peculiar destructive condition of the skeletal system resulting in spontaneous and progressive resorption and disappearance of osseous structures with replacement by vascular, fibrous connective tissue.
Nagaveni, N.B., Radhika, N.B., Satisha, T.S., Umashankara, K.V.   +3 more
core   +1 more source

Osteoblast–Osteoclast Coculture Amplifies Inhibitory Effects of FG‐4592 on Human Osteoclastogenesis and Reduces Bone Resorption

JBMR Plus, 2020
The link between bone and blood vessels is regulated by hypoxia and the hypoxia‐inducible transcription factor, HIF, which drives both osteogenesis and angiogenesis.
Philippa A Hulley, Ioanna Papadimitriou‐Olivgeri, Helen J Knowles   +2 more
doaj   +1 more source

MicroRNA-466 inhibits tumor growth and bone metastasis in prostate cancer by direct regulation of osteogenic transcription factor RUNX2. [PDF]

, 2017
MicroRNAs (miRNAs) have emerged as key players in cancer progression and metastatic initiation yet their importance in regulating prostate cancer (PCa) metastasis to bone has begun to be appreciated.
Colden, Melissa, Dahiya, Priya V, Dahiya, Rajvir, Dar, Altaf A, Majid, Shahana, Saini, Sharanjot, Shahryari, Varahram, Stein, Gary, Tanaka, Yuichiro, Yamamura, Soichiro   +9 more
core   +2 more sources

The Biology of Bone Metastasis [PDF]

, 2017
Bone metastasis, or the development of secondary tumors within the bone of cancer patients, is a debilitating and incurable disease. Despite its morbidity, the biology of bone metastasis represents one of the most complex and intriguing of all oncogenic ...
Esposito, Mark, Guise, Theresa, Kang, Yibin   +2 more
core   +1 more source

Prominent osteolysis in the maxilla: case report of an odontogenic fibroma mimicking a cyst

BMC Oral Health, 2023
Background Odontogenic fibroma (OF) is a rare benign odontogenic tumor of ectomesenchymal origin, mostly affecting the tooth-bearing portions of the jaws in middle-aged patients. Whilst small lesions tend to be clinically asymptomatic, varying unspecific
Clemens Raabe, Matthias Dettmer, Daniel Baumhoer, Valerie G. A. Suter   +3 more
doaj   +1 more source