Results 31 to 40 of about 15,355 (222)

Macrophages in aseptic loosening: Characteristics, functions, and mechanisms

Frontiers in Immunology, 2023
Aseptic loosening (AL) is the most common complication of total joint arthroplasty (TJA). Both local inflammatory response and subsequent osteolysis around the prosthesis are the fundamental causes of disease pathology.
Yehao Cong, Yehao Cong, Yi Wang, Tao Yuan, Zheng Zhang, Jianxun Ge, Qi Meng, Ziqing Li, Ziqing Li, Shui Sun, Shui Sun, Shui Sun   +11 more
doaj   +1 more source

The Effect of RANKL/OPG Balance on Reducing Implant Complications [PDF]

, 2017
Despite the phenomenal success of implants particularly in the realms of dentistry and orthopaedics, there are still challenges to overcome. The failure of implants resulting from infection, prosthetic loosening, and non-union continue to be the most ...
Giannoudis, P.V., Hatton, P.V., Jia, X., Kapasa, E.R., Yang, X.B.   +4 more
core   +3 more sources

Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease [PDF]

, 2014
Multiple myeloma (MM) is the second most common haematological malignancy and results in destructive bone lesions. The interaction between MM cells and the bone microenvironment plays an important role in the development of the tumour cells and MM ...
Blum B, Eriksen EF, Klein B, Lipton A, Mundy GR, Schmitt CP, Shay G   +6 more
core   +1 more source

THE MANAGEMENT OF CHARCOT MIDFOOT DEFORMITIES IN DIABETIC PATIENTS

Acta Medica, 2013
Charcot foot neuropathic osteoarthropathy is a disorder affecting the soft tissues, joints, and bones of the foot and ankle. The disease is triggered in a susceptible individual through a process of uncontrolled inflammation leading to osteolysis ...
Pavel Šponer, Tomáš Kučera, Jindra Brtková, Jaromír Šrot   +3 more
doaj   +1 more source

Peri-acetabular bone remodelling after uncemented total hip arthroplasty with monoblock press-fit cups: an observational study

BMC Musculoskeletal Disorders, 2020
Background Bone stock preservation in total hip replacement is essential to allow for later revisions in an increasingly younger and fitter index patient population.
Conrad Anderl, Georg Mattiassich, Reinhold Ortmaier, Martin Steinmair, Josef Hochreiter   +4 more
doaj   +1 more source

Serratiopeptidase reduces the invasion of osteoblasts by Staphylococcus aureus [PDF]

, 2017
Finding new strategies to counteract periprosthetic infection and implant failure is a main target in orthopedics. Staphylococcus aureus, the leading etiologic agent of orthopedic implant infections, is able to enter and kill osteoblasts, to stimulate ...
Arciola, Cr, Artini, M., Campoccia, D, Cellini, A, Ermocida, A, Ettorre, E, Montanaro, L, Papa, R, Selan, L, Vrenna, G   +9 more
core   +1 more source

XAF1 promotes osteoclast apoptosis by antagonizing the XIAP-caspase axis

Journal of Orthopaedic Translation
Background: Over-activated osteoclast (OC) is a major cause of diseases related to bone loss and bone metabolism. Both bone resorption inhibition and apoptosis induction of osteoclast are crucial in treating these diseases.
Mingchao Zhang, Yingkang Huang, Jinyu Bai, Wushuang Xu, Huajian Shan, Lei Sheng, Xiang Gao, Yu Han, Shiyou Wang, Chaowen Bai, Bo Tian, Yichao Ni, Qirong Dong, Feng Ma, Xiaozhong Zhou   +14 more
doaj   +1 more source

Male gender, Charnley class C, and severity of bone defects predict the risk for aseptic loosening in the cup of ABG I hip arthroplasty [PDF]

, 2010
Background We studied which factor could predict aseptic loosening in ABG I hip prosthesis with hydroxyapatite coating. Aseptic loosening and periprosthetic osteolysis are believed to be caused, at least in part, by increased polyethylene (PE) wear rate ...
Jiri Gallo, Vitezslav Havranek, Jana Zapletalova, Jiri Lostak   +3 more
core   +1 more source

Lattice Structures for Bone Replacement: The Intersection of Bone Biomechanics, Lattice Design, and Additive Manufacturing

Advanced Materials Technologies, EarlyView.
This review outlines how understanding bone's biology, hierarchical architecture, and mechanical anisotropy informs the design of lattice structures that replicate bone morphology and mechanical behavior. Additive manufacturing enables the fabrication of orthopedic implants that incorporate such structures using a range of engineering materials ...
Stylianos Kechagias, Maxwell J. Munford, Frederik C.H. Masure, Richard J. van Arkel, Reece N Oosterbeek   +4 more
wiley   +1 more source

The Role Of BMPs in the Regulation of Osteoclasts Resorption and Bone Remodeling: From Experimental Models to Clinical Applications

Frontiers in Immunology, 2022
In response to mechanical forces and the aging process, bone in the adult skeleton is continuously remodeled by a process in which old and damaged bone is removed by bone-resorbing osteoclasts and subsequently is replaced by new bone by bone-forming ...
Tatjana Bordukalo-Nikšić, Vera Kufner, Slobodan Vukičević   +2 more
doaj   +1 more source