Results 41 to 50 of about 15,355 (222)
IL-11 is essential in promoting osteolysis in breast cancer bone metastasis via RANKL-independent activation of osteoclastogenesis [PDF]
Cell Death & Disease, 2019 AbstractA variety of osteolytic factors have been identified from breast cancer cells leading to osteolysis, but less is known about which factor plays an essential role in the initiation process prior to the overt vicious osteolytic cycle. Here, we present in vitro and in vivo evidences to clarify the role of interleukin-11 (IL-11) as an essential ...
Mengmeng Liang +11 more
openaire +2 more sources
Macrophage inhibits the osteogenesis of fibroblasts in ultrahigh molecular weight polyethylene (UHMWPE) wear particle-induced osteolysis [PDF]
, 2019 Background In the ultrahigh molecular weight polyethylene (UHMWPE) prosthetic environment, fibroblasts affected by wear particles have the capacity of osteogenesis to reduce osteolysis.
Dai, Zixun +9 more
core +1 more source
Advanced Science, EarlyView.This study revealed how the osteoblastic microenvironment determines the fate of cancer cells disseminated in bone, with a focus on whether they colonize, reside in quiescence, or reactivate from dormancy. Targeting integrin signaling may offer promising strategies for preventing quiescent cancer cells reactivation and bone colonization.
Hong‐Li Wang +7 more
wiley +1 more source
Clinical-Paraclinical Features of Multiple Myeloma with Bone Affection [PDF]
Modern MedicineBone lesions are present in approximately 80–85% of patients with multiple myeloma at diagnosis. The most common sites of osteolysis include the spine (49–70%), ribs (45–50%), skull (35–50%), shoulder (20–35%), pelvis (30–40%), and long bones (13–35 ...
Gheorghe BURUIANA
doaj +1 more source
Advanced Science, EarlyView.Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong +6 more
wiley +1 more source
Molecular Medicine, 2021 Background Bone metastasis of colorectal cancer (CRC) often indicates a poor prognosis. Osteolysis can be observed in metastatic sites, implying an aberrant activation of osteoclasts.
Qian Jin +10 more
doaj +1 more source
Oestrogen deficiency modulates particle-induced osteolysis. [PDF]
, 2011 International audienceABSTRACT: INTRODUCTION: Postmenopausal osteoporosis may modulate bone response to wear debris. In this article, we evaluate the influence of oestrogen deficiency on experimental particle-induced osteolysis. METHODS: Polyethylene (PE)
Nich, Christophe +6 more
core +3 more sources
Advanced Science, EarlyView.It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló +2 more
wiley +1 more source
OSTEOPOROSIS AND JOINT REPLACEMENT
Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2018 Over the past few decades, the number of implantation of endoprosthetic joint replacements has steadily increased. Many patients who need joint replacements are of older age and have a reduced bone quality due to osteoporosis.
Holzer Gerold, Holzer Lukas A.
doaj +3 more sources
Frontiers in Pharmacology, 2018 Joint replacement is essential for the treatment of serious joint disease. However, prosthetic failure remains an important clinical issue, with periprosthesis osteolysis (PO), caused by osteoclastic bone resorption induced by wear particles, being the ...
Chuanlong Wu +10 more
doaj +1 more source