Results 81 to 90 of about 15,355 (222)

Reversal of MPPa‐PDT Resistance in Osteosarcoma by Targeting ROCK2‐Mediated Autophagy

Cell Proliferation, EarlyView.
ROCK2 competes with MST1 to bind to the aa 28‐198 region of SAV1 and then regulates the Hippo pathway to affect autophagy, resulting in the resistance of OS to MPPa‐PDT. Targeted inhibition of ROCK2 by screening for J059‐0149 increases the sensitivity of osteosarcoma to MPPa‐PDT. ABSTRACT Osteosarcoma (OS) is a primary bone tumour that occurs mostly in
Xuan Yi, Xueqiang Deng, Jianyong Deng, Chen Li, Hong Peng, Yunyan Du, Qing Li, Xiaohua Yan, Xin Hu, Yan Zheng, Shenliang Chen, Ting Xiong, Debin Xu, Leifeng Chen, Liang Hao   +14 more
wiley   +1 more source

Pim1 promotes the maintenance of bone homeostasis by regulating osteoclast function

Experimental and Molecular Medicine
The Pim1 (proviral integration site for Moloney leukemia virus 1) protein is a serine/threonine kinase that is essential for cell proliferation, apoptosis and innate immune responses. Here we show that Pim1 promotes osteoclast resorptive function without
Jeongin Seo, Ryeojin Ko, Minhee Kim, Jeongmin Seo, Hana Lee, Doyong Kim, Woojin Jeong, Han Sung Kim, Soo Young Lee   +8 more
doaj   +1 more source

New molecular targets in bone metastases [PDF]

, 2010
Bone metastases have a major impact on morbidity and on mortality in cancer patients. Despite its clinical relevance, metastasis remains the most poorly elucidated aspect of carcinogenesis.
Colucci, G., Fratto, M., Galluzzo, S., Gucciardino, C., LOMBARDI, LUCIO, Maiello, E., Pantano, F., Riva, E., RIZZO, Sergio, RUSSO, Antonio, SANTINI, Daniele, Silvestris, N., Tonini, G., Vincenzi, B., Zoccoli, A.   +14 more
core   +1 more source

Rate of MGUS Progression to Haematological Malignancies: A Systematic Review

European Journal of Haematology, EarlyView.
ABSTRACT Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic pre‐cancerous condition that precedes plasma cell dyscrasias, including multiple myeloma (MM). Current clinical guidelines report that MGUS's rate of malignant progression to haematological malignancy (HM) is ~1% per year; however, reported rates have varied widely ...
Stephen James Quinn, Chris Cardwell, Lesley Ann Anderson, Charlene McShane   +3 more
wiley   +1 more source

Radiological changes do not influence clinical mid-term outcome in stemless humeral head replacements with hollow screw fixation: a prospective radiological and clinical evaluation

BMC Musculoskeletal Disorders, 2018
Background Stemless shoulder arthroplasty is a fairly new concept. Clinical and radiological follow-up is essential to prove implant safety and concept. This prospective single-centre study was performed to evaluate the influence of radiological changes ...
Philipp R. Heuberer, Georg Brandl, Leo Pauzenberger, Brenda Laky, Bernhard Kriegleder, Werner Anderl   +5 more
doaj   +1 more source

Nuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients [PDF]

, 2016
Background: 8000 cases of renal cancer are diagnosed each year in the UK, with a five-year survival rate of 50 %. Treatment options are limited; a potential therapeutic target is the Src family kinases (SFKs).
Aitchison, Michael, Edwards, Joanne, Fraser, Siobhan, Hammond, Rachel, Jones, Robert J., Lim, Zhi, MacDonald, Alasdair I., Oades, Grenville M., Qayyum, Tahir, Roseweir, Antonia K.   +9 more
core   +1 more source

Alterations of bone proteins in medication‐related osteonecrosis of the jaw

European Journal of Oral Sciences, Volume 133, Issue 2, April 2025.
Abstract Changes in the protein expression pattern of osteoblastic lineage cells from the alveolar bone (OLAB) during medication‐related osteonecrosis of the jaw (MRONJ) have rarely been investigated. This lack of information is partly because of the limited availability of healthy samples and the lack of human alveolar bone cell lines for research ...
Andrea Schubert, Phillipp Brockmeyer, Philipp Kauffmann, Jan Wiegel, Florian Lautenbacher, Nicolai Miosge, Boris Schminke   +6 more
wiley   +1 more source

Bisphosphonates in multicentric osteolysis, nodulosis and arthropathy (MONA) spectrum disorder - an alternative therapeutic approach. [PDF]

, 2016
Multicentric osteolysis, nodulosis and arthropathy (MONA) spectrum disorder is a rare inherited progressive skeletal disorder caused by mutations in the matrix metalloproteinase 2 (MMP2) gene. Treatment options are limited.
Bonafé, L., Karall, D., Kotzot, D., Maurer, K., Mittaz-Crettol, L., Pichler, K., Rümmele-Waibel, A., Scholl-Bürgi, S., Steichen-Gersdorf, E., Superti-Furga, A., Wanschitz, J.   +10 more
core   +1 more source

Fatal spinal cord compression in a horse with chronic actinobacterial cranial nuchal bursitis

Equine Veterinary Education, EarlyView.
Summary A 14‐year‐old warmblood gelding was managed for waxing and waning cranial nuchal bursitis for 2 years. Intensive medical and surgical management was not curative, and the patient was subjected to euthanasia after becoming acutely recumbent. Ante‐mortem and post‐mortem next generation sequencing of bursal tissue and post‐mortem conventional PCR ...
H. Mesch, C. Frank, J. B. Daniels, E. Acutt, E. Contino   +4 more
wiley   +1 more source

Regulation of breast cancer induced bone disease by cancer-specific IKKβ [PDF]

, 2018
NFκB is implicated in breast cancer bone metastasis and skeletal remodelling. However, the role of IKKβ, a key component of the canonical NFκB pathway, in the regulation of breast cancer osteolytic metastasis has not been investigated.
Abu-Amer, Abu-Amer, Basaga, Bertrand, Cheng, Chirgwin, Coleman, Gaynor, Grimm, Hay, Hiraga, Hou, Hu, Hung, Inoue, Kaisho, Kang, Karin, Karin, Karin, Karin, Khoo, Lai, Lam, Lee, Lim, Lin, Lisanti, Löwik, Massagué, Massagué, Mundy, Nahta, Ohya, Olsen, Perrot-Applanat, Ralston, Ralston, Ralston, Roodman, Sasaki, Schiemann, Seo, Servant, Tanaka, Teti, Toker, Wang, Wang, Werb, White, Zhou   +51 more
core   +4 more sources