Results 21 to 30 of about 24,690 (186)

Single-Cell RNA Sequencing Reveals the Migration of Osteoclasts in Giant Cell Tumor of Bone

Frontiers in Oncology, 2021
Giant cell tumor of bone (GCTB) is benign tumor that can cause significant osteolysis and bone destruction at the epiphysis of long bones. Osteoclasts are thought to be highly associated with osteolysis in GCTB.
Wenyu Feng, Mingwei He, Mingwei He, Xiaohong Jiang, Xiaohong Jiang, Huijiang Liu, Tianyu Xie, Zhaojie Qin, Qian Huang, Shijie Liao, Chengsen Lin, Juliang He, Jiake Xu, Jie Ma, Yun Liu, Qingjun Wei   +15 more
doaj   +1 more source

Metformin suppresses UHMWPE particle-induced osteolysis in the mouse calvaria by promoting polarization of macrophages to an anti-inflammatory phenotype

Molecular Medicine, 2018
Background Implant failure remains a major obstacle to successful treatment via TJA. Periprosthetic osteolysis and aseptic loosening are considered as proof of wear debris-induced disruption of local regulatory mechanisms related to excessive bone ...
Zhao Yan, Xiaoxi Tian, Jinyu Zhu, Zifan Lu, Lifeng Yu, Dawei Zhang, Yanwu Liu, Chongfei Yang, Qingsheng Zhu, Xiaorui Cao   +9 more
doaj   +1 more source

Histopathological and Radiographic Features of the Postoperative Osteolysis Surrounding the PLLA Pin After the Fixation of the Osteochondral Fragment for Osteochondral Lesion of the Talus

Foot & Ankle Orthopaedics, 2019
Category: Ankle, Arthroscopy, Basic Sciences/Biologics Introduction/Purpose: Several surgical options are available for the treatment of osteochondral lesion of the talus (OLT).
Yasunari Ikuta MD, Tomoyuki Nakasa MD, Yusuke Tsuyuguchi MD, Yuki Ota MD, Munekazu Kanemitsu MD, Nobuo Adachi MD   +5 more
doaj   +1 more source

Role of Altered Metabolic Microenvironment in Osteolytic Metastasis

Frontiers in Cell and Developmental Biology, 2020
Metastatic bone disease is generally incurable and leads to pathological fractures, pain, hypercalcemia, spinal cord compression and decreased mobility.
Kerstin Tiedemann, Kerstin Tiedemann, Osama Hussein, Svetlana V. Komarova, Svetlana V. Komarova   +4 more
doaj   +1 more source

Risk Factors for Periacetabular Osteolysis and Wear in Asymptomatic Patients with Uncemented Total Hip Arthroplasties

The Scientific World Journal, 2014
Osteolysis is a silent disease leading to aseptic loosening. This has not been studied in a cohort of asymptomatic patients. The aim of this study was to detect factors that might be associated with the development of periacetabular osteolysis and wear ...
Buster Sandgren, Joakim Crafoord, Henrik Olivecrona, Göran Garellick, Lars Weidenhielm   +4 more
doaj   +1 more source

Prevention of wear particle-induced osteolysis by a novel V-ATPase inhibitor saliphenylhalamide through inhibition of osteoclast bone resorption.

PLoS ONE, 2012
Wear particle-induced peri-implant loosening (Aseptic prosthetic loosening) is one of the most common causes of total joint arthroplasty. It is well established that extensive bone destruction (osteolysis) by osteoclasts is responsible for wear particle ...
An Qin, Tak S Cheng, Zhen Lin, Lei Cao, Shek M Chim, Nathan J Pavlos, Jiake Xu, Ming Hao Zheng, Ke Rong Dai   +8 more
doaj   +1 more source

Mapping Tribo-Corrosion Behaviour of TI-6AL-4V Eli in Laboratory Simulated Hip Joint Environments

Lubricants, 2020
Wear and corrosion in artificial hip replacements are known to result in metal ion release and wear debris induced osteolysis. This may lead to pain and sensitivity for patients.
Ghulam Rasool, Yousuf El Shafei, Margaret M. Stack   +2 more
doaj   +1 more source

Long-term performance of oxidized zirconium on conventional and highly cross-linked polyethylene in total hip arthroplasty

SICOT-J, 2020
Introduction: Polyethylene wear and subsequent osteolysis remain obstacles to the long-term survivorship of total hip arthroplasty (THA). Highly cross-linked polyethylene (XLPE) with radical quenching represents a massive leap forward with dramatically ...
Carli Alberto V., Patel Anay R., Cross Michael B., Mayman David J., Carroll Kaitlin M., Pellicci Paul M., Jerabek Seth A.   +6 more
doaj   +1 more source

Incidentally discovered lacunar image of the mandible: A diagnostic orientation

Clinical Case Reports, 2022
Stafne bone cavity belongs to the class of pseudocysts as a mandibular radiolucency image with well‐defined borders. It is asymptomatic and incidentally discovered.
Rym Kammoun, Imen Chaabani, Touhami Ben Alaya   +2 more
doaj   +1 more source

Lattice Structures for Bone Replacement: The Intersection of Bone Biomechanics, Lattice Design, and Additive Manufacturing

Advanced Materials Technologies, EarlyView.
This review outlines how understanding bone's biology, hierarchical architecture, and mechanical anisotropy informs the design of lattice structures that replicate bone morphology and mechanical behavior. Additive manufacturing enables the fabrication of orthopedic implants that incorporate such structures using a range of engineering materials ...
Stylianos Kechagias, Maxwell J. Munford, Frederik C.H. Masure, Richard J. van Arkel, Reece N Oosterbeek   +4 more
wiley   +1 more source