Results 41 to 50 of about 24,690 (186)

DNA binding effects of LDH nanozyme for aseptic osteolysis mitigation through STING pathway modulation

Journal of Nanobiotechnology
Persistent and intense inflammation is recognized as the primary cause of wear-particle-induced aseptic osteolysis, which ultimately resulting in aseptic prosthesis loosening.
Zi Fu, Meng Zhang, Ying Huang, Han Wang, Wanting Hao, Zeyang Liu, Haiyan Guo, Dalong Ni   +7 more
doaj   +1 more source

A Dual‐Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor‐Associated Osteolysis Restoration via Sequential Release

Advanced Science, EarlyView.
The versatile CaO2@CuMOF@HAP nanohybrid demonstrates an outstanding MMP9/pH‐triggered release performance for sequential release of osteogenic growth peptide into deep‐seated tumor‐infiltrated bone destruction areas and dual ions into tumor cells, enabling efficient tumor‐associated osteolysis restoration and tumor elimination for more comprehensive ...
Lan Liu, Han‐Zhe Liu, Zhe‐Nan Liu, Tong Wang, Li‐Li Yu, Qiu‐Jing Li, Zi‐Yi Chen, Guo‐Feng Luo, Zheng‐Jun Shang   +8 more
wiley   +1 more source

Nanoscale ZnO doping in prosthetic polymers mitigate wear particle-induced inflammation and osteolysis through inhibiting macrophage secretory autophagy

Materials Today Bio
Wear particles produced by joint replacements induce inflammatory responses that lead to periprosthetic osteolysis and aseptic loosening. However, the precise mechanisms driving wear particle-induced osteolysis are not fully understood.
Zhuocheng Lyu, Xiangchao Meng, Fei Hu, Yuezhou Wu, Yurun Ding, Teng Long, Xinhua Qu, You Wang   +7 more
doaj   +1 more source

Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO

eLife, 2020
Inflammatory osteolysis is governed by exacerbated osteoclastogenesis. Ample evidence points to central role of NF-κB in such pathologic responses, yet the precise mechanisms underpinning specificity of these responses remain unclear.
Naga Suresh Adapala, Gaurav Swarnkar, Manoj Arra, Jie Shen, Gabriel Mbalaviele, Ke Ke, Yousef Abu-Amer   +6 more
doaj   +1 more source

Different Effects of Intramedullary Injection of Mesenchymal Stem Cells During the Acute vs. Chronic Inflammatory Phase on Bone Healing in the Murine Continuous Polyethylene Particle Infusion Model

Frontiers in Cell and Developmental Biology, 2021
Chronic inflammation is a common feature in many diseases of different organ systems, including bone. However, there are few interventions to mitigate chronic inflammation and preserve host tissue.
Takeshi Utsunomiya, Ning Zhang, Tzuhua Lin, Yusuke Kohno, Masaya Ueno, Masahiro Maruyama, Claire Rhee, Ejun Huang, Zhenyu Yao, Stuart B. Goodman, Stuart B. Goodman   +10 more
doaj   +1 more source

Skeletal pathologies in extant crocodilians as a window into the paleopathology of fossil archosaurs

The Anatomical Record, EarlyView.
Abstract Crocodilians, together with birds, are the only extant relatives to many extinct archosaur groups, making them highly important for interpreting paleopathological conditions in a phylogenetic disease bracketing model. Despite this, comprehensive data on osteopathologies in crocodilians remain scarce.
Alexis Cornille, Kyla Beguesse, Ewan Wolff, Clemens Zinner, Patrick Asbach, François Clarac, Florian Witzmann   +6 more
wiley   +1 more source

Micro-computed tomography derived anisotropy detects tumor provoked deviations in bone in an orthotopic osteosarcoma murine model. [PDF]

PLoS ONE, 2014
Radiographic imaging plays a crucial role in the diagnosis of osteosarcoma. Currently, computed-tomography (CT) is used to measure tumor-induced osteolysis as a marker for tumor growth by monitoring the bone fractional volume.
Heather A Cole, Tetsuro Ohba, Jiro Ichikawa, Jeffry S Nyman, Justin M M Cates, Hirotaka Haro, Herbert S Schwartz, Jonathan G Schoenecker   +7 more
doaj   +1 more source

Intraosseous sarcoidosis imitating peri‐implantitis: A case study

Clinical Advances in Periodontics, EarlyView.
Abstract Background Sarcoidosis is a multisystem granulomatous disorder of unknown cause, typically affecting the lungs and lymph nodes, but it can also involve the eyes, skin, heart, bones, and other organs. The exact cause is unclear, but genetic factors and environmental triggers like infections, chemicals, or dust may play a role.
Magdalena Orlowska, David S. Gottlieb, Kenneth S. Kornman   +2 more
wiley   +1 more source

Case report: Presumptive subcutaneous malignant peripheral nerve sheath tumor with intracranial invasion and osteolysis in the posterior fossa of a dog

Frontiers in Veterinary Science, 2022
A 13-year-old castrated male Toy Poodle presented with an acute vestibular disorder. Magnetic resonance imaging and computed tomography revealed a large oval space-occupying mass with skull destruction located from the subcutaneous tissue to the ...
Kyosuke Hidari, Yuya Nakamoto, Yuya Nakamoto, Keiichi Sakurai, Yoko Sakurai, Kazumi Nibe, Miwa Nakamoto   +6 more
doaj   +1 more source

Proteoglycans and Osteolysis [PDF]

, 2011
Osteolysis is a complex mechanism resulting from an exacerbated activity of osteoclasts associated or not with a dysregulation of osteoblast metabolism leading to bone loss. This bone defect is not compensated by bone apposition or by apposition of bone matrix with poor mechanical quality.
Baud'Huin, Marc, Charrier, Céline, Bougras, Gwenola, Brion, Régis, Lezot, Frédéric, Padrines, Marc, Heymann, Dominique   +6 more
openaire   +4 more sources