Results 61 to 70 of about 24,690 (186)

Saikosaponin A attenuates osteoclastogenesis and bone loss by inducing ferroptosis

Frontiers in Molecular Biosciences
To alleviate bone loss, most current drugs target osteoclasts. Saikosaponin A (Ssa), a triterpene saponin derived from Bupleurum falcatum (also known as Radix bupleuri), has immunoregulatory, neuromodulatory, antiviral, anticancer, anti-convulsant, anti ...
Tian-Qi Li, Tian-Qi Li, Yan Liu, Chong Feng, Chong Feng, Jin Bai, Jin Bai, Zi-Rou Wang, Xiang-Yu Zhang, Xin-Xing Wang   +9 more
doaj   +1 more source

Migrasomes, Matrix‐Bound Nanovesicles, and More: Messengers in the Matrix

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) and particles (EPs) are diverse micro‐ and nanoparticles that circulate in bodily fluids and can attach to, or be deposited onto, the extracellular matrix (ECM) and other surfaces. To date, the nomenclature and classification of matrix‐bound or matrix‐associated EVs and EPs (MEVPs) have been unclear, largely due to
Anna V. Kolesov, Natalie Reitz, Marley Dewey, Colin L. Hisey   +3 more
wiley   +1 more source

The inhibitory effects of 7ND protein on osteoclast differentiation in apical periodontitis

Frontiers in Cellular and Infection Microbiology
BackgroundApical periodontitis (AP) is a highly prevalent inflammatory condition that affects the tissue surrounding the apex of a tooth root. 7ND protein, a mutant form of monocyte chemoattractant protein-1 (MCP-1), functions as a dominant negative ...
Zhang-Zhang Ji, Xiu-Min Xu, Yu-Lin Lu, Run-Zhen Zhang, Ying Zhang, Zhi-Hui Zou, Qi Xu   +6 more
doaj   +1 more source

A Large Skull Defect Due to Gorham-Stout Disease: Case Report and Literature Review on Pathogenesis, Diagnosis, and Treatment

Frontiers in Endocrinology, 2020
A 24-year old man was referred to the Erasmus MC Bone Center because of an asymptomatic increasing skull defect of the left parietal bone. The defect was first noticed at the age of six, and gradually increased over the years.
Catherine E. de Keyser, Michael S. Saltzherr, Eelke M. Bos, M. Carola Zillikens   +3 more
doaj   +1 more source

Imaging of Abdominal Complications in Children With Acute Lymphoblastic Leukaemia

Journal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy and remains one of the most common causes of cancer‐related death in children and adolescents. Five‐year overall survival rates now exceed 90% with current multidrug chemotherapeutic regimens. This improvement, coupled with the toxicity of chemotherapy, has led to the
Luke R. Holmes, Rishi S. Kotecha, Derek J. Roebuck   +2 more
wiley   +1 more source

The use of biocomposite vented anchors for arthroscopic remplissage allows for better bony ingrowth than peek vented anchors: A volumetric CT study of 85 anchors

Journal of Experimental Orthopaedics
Purpose To evaluate whether the use of polyetheretherketone (PEEK) or biocomposite vented anchors has any impact on bony ingrowth inside the anchor or implant‐related osteolysis after implantation during remplissage for Hill‐Sachs defects (HSD) in ...
Miguel Angel Ruiz Ibán, Rosa Vega, Raquel Ruiz Díaz, Cristina Delgado, Umile Giuseppe Longo, Jorge Diaz Heredia   +5 more
doaj   +1 more source

Reversal of MPPa‐PDT Resistance in Osteosarcoma by Targeting ROCK2‐Mediated Autophagy

Cell Proliferation, EarlyView.
ROCK2 competes with MST1 to bind to the aa 28‐198 region of SAV1 and then regulates the Hippo pathway to affect autophagy, resulting in the resistance of OS to MPPa‐PDT. Targeted inhibition of ROCK2 by screening for J059‐0149 increases the sensitivity of osteosarcoma to MPPa‐PDT. ABSTRACT Osteosarcoma (OS) is a primary bone tumour that occurs mostly in
Xuan Yi, Xueqiang Deng, Jianyong Deng, Chen Li, Hong Peng, Yunyan Du, Qing Li, Xiaohua Yan, Xin Hu, Yan Zheng, Shenliang Chen, Ting Xiong, Debin Xu, Leifeng Chen, Liang Hao   +14 more
wiley   +1 more source

Rate of MGUS Progression to Haematological Malignancies: A Systematic Review

European Journal of Haematology, EarlyView.
ABSTRACT Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic pre‐cancerous condition that precedes plasma cell dyscrasias, including multiple myeloma (MM). Current clinical guidelines report that MGUS's rate of malignant progression to haematological malignancy (HM) is ~1% per year; however, reported rates have varied widely ...
Stephen James Quinn, Chris Cardwell, Lesley Ann Anderson, Charlene McShane   +3 more
wiley   +1 more source

Alterations of bone proteins in medication‐related osteonecrosis of the jaw

European Journal of Oral Sciences, Volume 133, Issue 2, April 2025.
Abstract Changes in the protein expression pattern of osteoblastic lineage cells from the alveolar bone (OLAB) during medication‐related osteonecrosis of the jaw (MRONJ) have rarely been investigated. This lack of information is partly because of the limited availability of healthy samples and the lack of human alveolar bone cell lines for research ...
Andrea Schubert, Phillipp Brockmeyer, Philipp Kauffmann, Jan Wiegel, Florian Lautenbacher, Nicolai Miosge, Boris Schminke   +6 more
wiley   +1 more source

Periprosthetic Osteolysis

Orthopedics, 2008
The Case An 86-year-old man with prior left total hip arthroplasty presented with left hip pain. Figure: AP radiograph of the left hip.
Madhura A. Desai, Laura W. Bancroft
openaire   +2 more sources