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Osteomyelitis [PDF]

open access: yesNew England Journal of Medicine, 1997
Bone and joint infections are painful for patients and frustrating for both them and their doctors. The high success rates of antimicrobial therapy in most infectious diseases have not yet been achieved in bone and joint infections owing to the physiological and anatomical characteristics of bone.
Lew, Daniel Pablo, Waldvogel, Francis
openaire   +5 more sources

Choosing the right animal model for osteomyelitis research: Considerations and challenges

open access: yesJournal of Orthopaedic Translation, 2023
Osteomyelitis is a debilitating bone disorder characterized by an inflammatory process involving the bone marrow, bone cortex, periosteum, and surrounding soft tissue, which can ultimately result in bone destruction.
Shen Huang   +4 more
doaj   +1 more source

Mechanisms of Antibiotic Failure During Staphylococcus aureus Osteomyelitis

open access: yesFrontiers in Immunology, 2021
Staphylococcus aureus is a highly successful Gram-positive pathogen capable of causing both superficial and invasive, life-threatening diseases. Of the invasive disease manifestations, osteomyelitis or infection of bone, is one of the most prevalent ...
B. Gimza, J. Cassat
semanticscholar   +1 more source

Clinical and anatomical traits of orthopaedic traumatic and maxillofacial osteomyelitis: a systematic review

open access: yesКубанский научный медицинский вестник, 2021
Background. Chronic osteomyelitis requires a multidisciplinary approach. The main contributors are physicians of two specialties, orthopaedic trauma and maxillofacial surgeons, depending on the pathology’s localisation. Each specialty often relies on its
S. V. Baranov   +2 more
doaj   +1 more source

Recent advances in the local antibiotics delivery systems for management of osteomyelitis

open access: yesDrug Delivery, 2021
Chronic osteomyelitis is a challenging disease due to its serious rates of mortality and morbidity while the currently available treatment strategies are suboptimal.
Reem Khaled Wassif   +3 more
semanticscholar   +1 more source

In vitro and in vivo assessment of caprine origin Staphylococcus aureus ST398 strain UTCVM1 as an osteomyelitis pathogen

open access: yesFrontiers in Cellular and Infection Microbiology, 2022
Staphylococcus aureus (SA) is a significant and well-recognized causative organism of bacterial osteomyelitis. Osteomyelitis is an inflammatory bone disease characterized by progressive bone destruction and loss. This disease causes significant morbidity
Caroline Billings   +8 more
doaj   +1 more source

Biomimetic Nanomedicine-Triggered in Situ Vaccination for Innate and Adaptive Immunity Activations for Bacterial Osteomyelitis Treatment.

open access: yesACS Nano, 2021
The development of bacterial vaccines for inducing an immunoresponse against infectious diseases such as osteomyelitis is of great significance and importance.
Han Lin   +6 more
semanticscholar   +1 more source

3D-Printed Multifunctional Polyetheretherketone Bone Scaffold for Multimodal Treatment of Osteosarcoma and Osteomyelitis.

open access: yesACS Applied Materials and Interfaces, 2021
In this work, we developed the first 3D-printed polyetheretherketone (PEEK)-based bone scaffold with multi-functions targeting challenging bone diseases such as osteosarcoma and osteomyelitis.
Ce Zhu   +14 more
semanticscholar   +1 more source

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