Results 101 to 110 of about 39,566 (236)
Genetic Determinants of Treatment‐Related Bone Toxicity in Pediatric Acute Lymphoblastic Leukemia
Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 786-794, September 2026.Osteonecrosis and fractures are serious corticosteroid‐induced bone toxicities in children treated for acute lymphoblastic leukemia, yet their genetic determinants remain incompletely defined. In this study, we aimed to identify novel genetic contributors to bone toxicity and to evaluate the robustness of both newly identified and previously ...
Rachid Abaji +14 more
wiley +1 more source
Type 5 Diabetes Mellitus: Pathophysiology, Clinical Phenotype, and Nutritional Management
Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.ABSTRACT Type 5 Diabetes Mellitus (T5DM) is an emerging diabetes phenotype linked to chronic undernutrition. It predominantly affects young, lean individuals in low‐ and middle‐income countries. After its formal recognition by the International Diabetes Federation in 2025, T5DM resurfaced as a clinically relevant insulin‐deficient phenotype.
İrem Nur Şahin Anılgan +1 more
wiley +1 more source
Impacted Bones: Can Extant Primates Help Identify Tool Use in Early Hominins?
Evolutionary Anthropology: Issues, News, and Reviews, Volume 35, Issue 3, September 2026.ABSTRACT Despite recent advances pushing back the earliest record of tool use, how and when it first emerged in hominins, and the extent to which it featured amongst the numerous co‐existing species, remain critical questions in paleoanthropology. In addition to analyzing fossils and lithic toolkits, novel strides in understanding this might be made by
Rachel M. Hurwitz +3 more
wiley +1 more source
Clinical Genetics, Volume 110, Issue 3, Page 363-368, September 2026.FIG4 is essential for lysosomal homeostasis. FIG4‐related disorders present as a continuous spectrum from the juvenile lethality in Yunis‐Varon syndrome to an increased risk of amyotrophic lateral sclerosis (ALS) in adult life. FIG4‐related disorders comprise a novel group of disorders of lysosomal homeostasis and can be classified into severe ...
Pankaj Prasun, Matthew Rasberry
wiley +1 more source
Cancer, Volume 132, Issue 16, 15 August 2026.Abstract Background Bisphosphonates (BPs) are routinely used as an adjuvant therapy for breast cancer to reduce the risk of bone recurrences given their anti‐resorptive effects on bones and antitumor characteristics. However, there remains limited evidence regarding their utility across different subtypes. Methods In this population‐based cohort study,
Liuye Huang +8 more
wiley +1 more source
Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain
Advanced Science, Volume 13, Issue 46, 17 August 2026.Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh +7 more
wiley +1 more source
Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis
Advanced Science, Volume 13, Issue 44, 7 August 2026.Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao +28 more
wiley +1 more source
Genes Associated With Fracture Risk in Thoroughbred Horses Have Novel Roles in Osteogenesis
Animal Genetics, Volume 57, Issue 4, August 2026.ABSTRACT Bone fractures in Thoroughbred racehorses are a major welfare problem. Genetic factors contribute to fracture risk. Cell models have previously identified 112 differentially expressed genes in bone‐forming osteoblasts derived from horses at high and low genetic risk of fracture. However, 42 of these genes have no published role in bone.
Amy C. Ross +5 more
wiley +1 more source
American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1773-1782, August 2026.ABSTRACT The Homologous Recombination Factor With OB‐Fold (HROB) plays a role in homologous recombination and DNA replication, where it enhances the MCM8‐MCM9 helicase complex activity. Recent findings link biallelic germline HROB variants to primary gonadal insufficiency (hypergonadotropic hypogonadism), a phenotype also associated with MCM8/MCM9 ...
Noah C. Helderman +15 more
wiley +1 more source