Results 81 to 90 of about 39,566 (236)

Treatment Goals for Primary Biliary Cholangitis, an Australian Perspective

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Primary biliary cholangitis (PBC) is an autoimmune liver disease that targets the small intrahepatic bile ducts with diagnosis based on elevated serum alkaline phosphatase (ALP) levels and the presence of anti‐mitochondrial antibodies. Untreated, it may run a progressive course to cirrhosis and hepatic decompensation, at which point liver ...
Simone I. Strasser, Alexander J. Thompson, Rohit Gupta, John Lubel, Janine French, Beverly Sacks, Martin Weltman   +6 more
wiley   +1 more source

CHARGE Syndrome: A Narrative Review and Update on Diagnosis, Assessment and Management

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Background CHARGE syndrome (CS) is a rare multisystemic genetic condition caused by a pathogenic variant in the DNA‐binding protein‐7 CHD7 gene. The condition affects the development of neural crest cells, which give rise to craniofacial structures, cranial nerves, ears, eyes and the heart, resulting in diverse and complex clinical features ...
Eleni M. van Gelder, Suzanna E. L. Temple, Niall Jefferson, David Brown, Kasee Stratton‐Gadke, Madelene Rich, Steve Rose, Kim Blake   +7 more
wiley   +1 more source

Osteoporosis and Periodontitis: Two‐Way Epidemiological and Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review investigates the main mechanistic pathways connecting local periodontitis to systemic osteoporosis. Seven interconnected mechanisms are identified. ABSTRACT Osteoporosis and periodontitis are highly prevalent, chronic inflammatory diseases that constitute a major global health burden.
Jia Chang, Geeta Madhuri Bhuvanagiri, Megan Dulkanchainun, Cunyu Wang   +3 more
wiley   +1 more source

Discovery and Identification of Serum Succinyl‐Proteome for Postmenopausal Women with Osteoporosis and Osteopenia

Orthopaedic Surgery, 2019
Objective For the purpose of providing evidence for the treatment of osteoporosis and osteopenia, this study retrospectively identified succinylation‐modified sites and proteins in postmenopausal women, and bioinformatics analysis were performed. Methods
Li‐li Zhang, Chun‐wen Li, Kang Liu, Zhong Liu, Bo‐cheng Liang, Yi‐ran Yang, Xiao‐lin Shi   +6 more
doaj   +1 more source

The Effects of Rapid Periodontal Distraction on Tooth Vitality and Bone Quality/Quantity: A Split‐Mouth Experimental Design

Orthodontics &Craniofacial Research, EarlyView.
ABSTRACT Objectives Periodontal distraction (PD) osteogenesis is a minimally invasive technique capable of rapidly moving uniradicular teeth, thereby shortening orthodontic treatment time. This study aimed to determine whether: (1) PD‐induced tooth movement affects tooth vitality and (2) the regenerated bone meets restorative standards for implant ...
Parul Sangwan, Ying Liu, Phillip M. Campbell, Michael Ellis, Yan Jing, Peter H. Buschang   +5 more
wiley   +1 more source

The triangular relationship of serum uric acid, osteoporosis or osteopenia, and body mass index for men and postmenopausal women

Scientific Reports
Osteoporosis (OP) is a systemic bone disease characterized by reduced bone density and quality, leading to increased bone fragility and a higher risk of fractures.
Ziran Xiu, Zhengnan Gao, Lan Luo
doaj   +1 more source

Association between C-reactive protein-triglyceride glucose index and abnormal BMD in middle-aged and elderly patients with type 2 diabetes mellitus: a cross-sectional study

Frontiers in Medicine
Background and aimsBone loss is an irreversible physiological change occurring with age. Type 2 diabetes mellitus (T2DM) is associated with poor bone health, and insulin resistance (IR) and inflammation are common pathologic mechanisms in T2DM and ...
Yuan Zhang, Yali Jing
doaj   +1 more source

Cardiometabolic Multimorbidity Increases the Risk of Hip Fracture: A Longitudinal Cohort Study Based on CHARLS

Orthopaedic Surgery, EarlyView.
CMM increase the risk of hip fracture, especially in relatively younger individuals and participants with a history of falls. From the perspective of CMM, controlling the number of chronic conditions is expected to block the risk–amplifying effect of multimorbidity on hip fracture and reduce the cost of intervention. ABSTRACT Background Cardiometabolic
Peng Tian, Shaoxiong Du, Run Tian, Weidong Zhu, Chunsheng Wang, KunZheng Wang, Pei Yang, Xin Huang   +7 more
wiley   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

Relationship of lumbar vertebral volumetric bone mineral density with trunk muscle density assessed by quantitative computed tomography in maintenance hemodialysis patients

Renal Failure
Background Sarcopenia due to abnormal muscle metabolism and osteoporosis due to abnormal bone metabolism are common complications in maintenance hemodialysis (MHD) patients. The aim of this study was to investigate the association between volumetric bone
Lijiao Yang, Liping Zhang, Xiaoguang Cheng, Ling Wang, Chao Wang, Dongliang Zhang   +5 more
doaj   +1 more source