Results 151 to 160 of about 54,052 (278)
Periodontology 2000, EarlyView.Abstract Background/Aim Antiresorptive therapy represents a cornerstone in the management of osteoporosis and cancer‐related bone disease through suppression of osteoclast‐mediated bone resorption. As implant therapy becomes more common in aging populations, clinicians increasingly encounter patients receiving these medications, thus making their ...
Emilio A. Cafferata +2 more
wiley +1 more source
Osteopontin: a key regulator of liver lipid metabolism
, 2016 El contenido de los capítulos C,D,E,F,G e I están sujetos a confidencialidad 78 p. [168 p.]Osteopontin deficiency protects from obesity-related hepatosteatosis and liver fibrosis.
Núñez García, Maitane
core +1 more source
Elevated osteopontin levels in active relapsing-remitting multiple sclerosis
, 2003 In the search for proteins that might play a role in the pathogenesis of multiple sclerosis (MS), osteopontin (OPN) has been identified as the most prominent cytokine-encoding gene expressed within MS lesions.
Polman, C.H. +4 more
core
Experimental Physiology, EarlyView.ABSTRACT Ascending thoracic aortic aneurysm formation differs fundamentally between patients with bicuspid (BAV) and tricuspid (TAV) aortic valve phenotypes, yet current clinical management largely relies on shared diameter thresholds, although clinical and scientific data fail to correlate with diameter and risk of rupture.
Riaz Akhtar +3 more
wiley +1 more source
A Pyrrole-Imidazole Polyamide Targeting Human USF1 Binding Suppresses High Glucose-Induced TGF-β1 and Osteopontin Expression in Human Renal Mesangial Cells. [PDF]
CellsAkiya Y +4 more
europepmc +1 more source
Experimental Physiology, EarlyView.Abstract Atrial fibrillation (AF) prevalence rises sharply with age due to two independent mechanisms. Ageing produces irreversible arrhythmogenic substrate changes through progressive fibrosis, cellular senescence and mitochondrial dysfunction, while modifiable risk factors such as obesity, hypertension, sleep apnoea, diabetes and alcohol use promote ...
Udit Thakur, Jonathan M. Kalman
wiley +1 more source
Senolytics and exercise: Dual modalities for rejuvenating muscle
The Journal of Physiology, EarlyView.Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican +4 more
wiley +1 more source
Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies
The Journal of Physiology, EarlyView.Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu +3 more
wiley +1 more source
From Regenerative to Degenerative Niche: Multicellular Crosstalk and Population Dynamics in Skeletal Muscle Aging. [PDF]
Aging CellAging transforms the skeletal muscle microenvironment from a balanced, regenerative niche into a maladaptive, degenerative state. This review highlights how disrupted multicellular crosstalk drives chronic inflammation, fibrosis, and neuromuscular dysfunction, ultimately compromising tissue repair and fueling sarcopenia.
Kim S, Kim MJ, Yang YR.
europepmc +2 more sources