Results 181 to 190 of about 462,772 (320)

The Effects of Risedronate Therapy Combined With Vitamin D and Calcium on Biochemical Markers of Bone Turnover and Bone Mineral Density in Postmenopausal Osteoporosis

, 2004
The aim of the study was to investigate the effects of risedronate therapy combined with vitamin D and calcium on bone mineral density(BMD) and biochemical markers of bone turnover in patients with primary postmenopausal osteoporosis.
Sacide Atalay, Nuriye Gürer, Can Bora Önder, Hilal Sekban, Cengiz Bahadır, Hüsniye Koç   +5 more
core  

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

A systematic review and meta-analysis of efficacy and safety of Romosozumab in postmenopausal osteoporosis

Osteoporosis International, 2021
S. Singh, S. Dutta, S. Khasbage, T. Kumar, J. Sachin, J. Sharma, S. Varthya   +6 more
semanticscholar   +1 more source

WTAP Transcriptional Suppression by KLF9 Drives Osteoclastogenesis via M6A‐Mediated Regulation of CSF1R Signaling in Estrogen‐Deficient Osteoporosis

Advanced Science, Volume 13, Issue 60, 28 October 2026.
Scheme of the KLF9/WTAP/YTHDF2/m6A/CSF1R regulatory axis in osteoclastogenesis and estrogen‐deficient osteoporosis. WTAP‐mediated m6A modification of Csf1r mRNA governs osteoclastogenesis via a YTHDF2‐mediated pathway. Pathological upregulation of KLF9 drives Wtap transcription, leading to increased m6A deposition on the 3’‐UTR of Csf1r mRNA.
Chen Shen, Xin Liu, Gaoran Ge, Li Xu, Ziyu Zhang, Chang Lv, Hao Xu, Wenhao Li, Yi Qin, Qifeng Sheng, Qihan Wang, Hongxia Li, Jun Zhou, Huilin Yang, Dechun Geng   +14 more
wiley   +1 more source

Two Years of Alendronate and Calcitonin Treatments for Osteoporosis in Postmenopausal Women - Original Investigation

, 2006
This study was to compare and research the effects of alendronate and calcitonin treatments with 2 years duration in women with postmenopausal osteoporosis.
Gülnur Taşçı Bozbaş, Engin Taştaban, Ömer Faruk Şendur, Gülcan Gürer   +3 more
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Biologic and Targeted Synthetic Disease‐Modifying Antirheumatic Drugs Do Not Arrest Bone Loss in Patients With Rheumatoid Arthritis: A Long‐Term Multicenter Observational Study

Arthritis &Rheumatology, Volume 78, Issue 10, Page 2036-2049, October 2026.
Objective Osteoporosis causes fractures that further increase the disease burden of rheumatoid arthritis (RA); however, osteoporosis treatment rates remain low. Although several studies have reported that biologic or targeted synthetic disease‐modifying antirheumatic drugs (b/tsDMARDs) can prevent or improve osteoporosis in RA, our large‐scale, real ...
Takafumi Aritomi, Koshiro Sonomoto, Shingo Nakayamada, Hiroaki Tanaka, Atsushi Nagayasu, Satoshi Kubo, Ippei Miyagawa, Ayako Yamaguchi, Naoaki Ohkubo, Yasuyuki Todoroki, Yurie Satoh‐Kanda, Masanobu Ueno, Ryuichiro Kanda, Yuya Fujita, Masashi Funada, Hidenori Sakai, Satsuki Matsunaga, Hiroaki Tanaka, Masayuki Shinojima, Hiroki Kawamura, Kazuki Takahashi, Miyabi Ando, Kazuki Haru, Yusuke Miyazaki, Kentaro Hanami, Masao Nawata, Shunsuke Fukuyo, Keisuke Nakatsuka, Mikiko Tokunaga, Kazuyoshi Saito, Yoshiya Tanaka   +30 more
wiley   +1 more source

Comparison of Different Treatment Protocols in Osteoporosis

, 2003
The aim of this study was to compare the effectiveness of different medical treatment protocols in osteoporosis. For this purpose 153 postmenopausal women who were diagnosed as osteoporosis were randomly divided into 4 groups and given different medical ...
Ali Aydeniz, Mustafa Güler, Ömer Faruk Şendur   +2 more
core  

Ensemble‐Based Machine Learning Models for Classifying Intervention‐Related Psychological Outcome Patterns in Menopausal Women Treated With Pimpinella anisum

Brain and Behavior, Volume 16, Issue 10, October 2026.
This study develops an ensemble‐based machine learning approach to detect and predict psychological disorders in menopausal women using clinical and questionnaire data. Random Forest achieved the best performance. The framework supports early risk identification and integrates statistical validation with Unani‐based and home remedy interventions to ...
Md Belal Bin Heyat, Arshiya Sultana, Attiq Ur Rehman, Arfa Begum, Mohamad Sawan   +4 more
wiley   +1 more source

The Effect of Alendronate and Calcitonin Treatments on Bone Mineral Density and Quality of Life in Women With Postmenopausal Osteoporosis

, 2002
The aim of this study was to compare the effect of alendronate and calcitonin treatments on bone mineral density (BMD) and quality of life of women with postmenopausal osteoporosis.
İ. Dalkıran, F. Taşçıoğlu, C. Öner, E. Sırmagül, O. Armağan   +4 more
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Synthesis of a Series of Heterocyclic N‐Substituted Derivatives of Alendronic Acid and Their Preliminary Biological Evaluation

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
The influence of pyridyl and imidazole substituents on the biological properties of alendronate derivatives is investigated. A series of heterocyclic N‐substituted bisphosphonates is synthesized and evaluated for hydroxyapatite binding and antiproliferative activity.
Anna Nasulewicz‐Goldeman, Tomasz M. Goszczyński, Joanna Wietrzyk, Waldemar Goldeman   +3 more
wiley   +1 more source