Results 71 to 80 of about 472,200 (335)

Skeletal Aging and Osteoporosis: Mechanisms and Therapeutics

International Journal of Molecular Sciences, 2021
Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone homeostasis, which is maintained by an intricate balance between bone formation and bone resorption, undergoes deregulation.
Abhishek Chandra, J. Rajawat
semanticscholar   +1 more source

Anionic Citrate‐Based 3D‐Printed Scaffolds for Tunable and Sustained Orthobiologic Delivery to Enhance Tissue Regeneration

Advanced Functional Materials, EarlyView.
A potent anionic citric acid‐based 3D‐printed scaffold is developed for the sustained and controlled release of orthobiologics to enhance orthopedic therapeutic efficacy. Comprehensive in vivo studies demonstrated effective bone fusion and high safety at a low dose of BMP‐2 delivered by the system, establishing it as a promising platform for safe ...
Se‐Hwan Lee, Ruqiang Lu, Andrew House, Zizhao Li, Lindsey Hammond Burton, Katie Josephine Sikes, Lynn Marie Pezzanite, Drew William Koch, Kevin Michael Labus, Ben Gadomski, Jeremiah Easley, Richard Tuan Tran, Su Chin Heo   +12 more
wiley   +1 more source

The role of the P2X7 receptor on bone loss in a mouse model of inflammation-mediated osteoporosis

Bone Reports, 2017
In inflammatory autoimmune diseases, bone loss is frequent. In most cases, secondary osteoporosis is caused by treatment with systemic glucocorticoid. However, the pathogenesis behind the bone loss is presumed multifactorial.
T.M. Kvist, S. Syberg, S. Petersen, M. Ding, N.R. Jørgensen, P. Schwarz   +5 more
doaj   +1 more source

The relationship between anthropometric parameters and bone mineral density in an Iranian referral population [PDF]

, 2014
Osteoporosis is a common health concern in both developed and developing countries. In this study the association between anthropometric measures and osteoporosis was investigated in 3630 males and females visiting BMD clinic of Shariati Hospital, Tehran,
Fakhari, Sima, Khashayar, Patricia, Larijani, Bagher, Rezaei Hemami, Mohsen, Soltani, Akbar   +4 more
core   +1 more source

Prevention and management of osteoporotic fractures by non-physician health professionals: a systematic literature review to inform EULAR points to consider [PDF]

, 2020
Objective To perform a systematic literature review (SLR) about the effect of non-pharmacological interventions delivered by non-physician health professionals to prevent and manage osteoporotic fractures. Methods Eight clinical questions based on two
Adams, Jo, Bakkers, Margot, Balážová, Petra, Baxter, Mark, Blavnsfeldt, Anne-Birgitte, Briot, Karine, Chiari, Catharina, Cooper, Cyrus, de la Torre, Jenny, Dragoi, Razvan, Gäbler, Gabriele, Hurkmans, Emailie, Lems, Willem, Mosor, Erika, Pais, Sandra, Simon, Cornelia, Stamm, Tanja A, Studenic, Paul, Tilley, Simon, Wilson, Nicky   +19 more
core   +1 more source

Romosozumab Treatment in Postmenopausal Women with Osteoporosis.

New England Journal of Medicine, 2016
BACKGROUND Romosozumab, a monoclonal antibody that binds sclerostin, increases bone formation and decreases bone resorption. METHODS We enrolled 7180 postmenopausal women who had a T score of -2.5 to -3.5 at the total hip or femoral neck. Patients were
F. Cosman, D. Crittenden, J. Adachi, N. Binkley, E. Czerwiński, S. Ferrari, L. Hofbauer, E. Lau, E. Lewiecki, A. Miyauchi, C. Zerbini, Cassandra E. Milmont, Li Chen, J. Maddox, P. Meisner, C. Libanati, A. Grauer   +16 more
semanticscholar   +1 more source

Glucocorticoids Alter Bone Microvascular Barrier via MAPK/Connexin43 Mechanisms

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Osteoporosis induced by Glucocorticoids (GCs) is a common complication of long‐term GC use in patients with inflammatory and autoimmune conditions, often leading to an increased fracture risk. A 3D bicellular endo‐osteo microfluidic platform is developed to explore pathogenic mechanisms underlying GCs‐induced osteoporosis, highlighting a novel MAPK ...
Eun‐Jin Lee, Peter Lialios, Micaila Curtis, James Williams IV, Yoontae Kim, Paul Salipante, Steven Hudson, Mandy B. Esch, Moshe Levi, Joanna Kitlinska, Stella Alimperti   +10 more
wiley   +1 more source

Change in bone mineral density in post menopausal women with rheumatoid arthritis [PDF]

, 2013
Introduction: Low bone mass is a serious complication of post menopausal women with rheumatoid arthritis. We determined the Change in Bone Mineral Density in postmenopausal women with rheumatoid arthritis.
Aghaei, M., Aili, A., Jamshir, M., Khani, S.H., Mohebi, E.G., Pour, N.B., Sedighi, S., Shirashiani, M., Shojaa, M., Zayeni, H.   +9 more
core   +1 more source

European guidance for the diagnosis and management of osteoporosis in postmenopausal women

Osteoporosis International, 2018
SummaryGuidance is provided in a European setting on the assessment and treatment of postmenopausal women at risk from fractures due to osteoporosis.IntroductionThe International Osteoporosis Foundation and European Society for Clinical and Economic ...
J. Kanis, C. Cooper, R. Rizzoli, J. Reginster, on behalf of the International Osteoporosis Foundation   +4 more
semanticscholar   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source