OTEH-11. Single Cell RNA Sequencing to identify cellular heterogeneity with in Pituitary Adenomas [PDF]
Neurooncol Adv, 2021 Abstract Pituitary adenomas (PA) are one of the most common primary brain tumors and comprise approximately 15% of brain neoplasms. Most PA are histologically benign, but can cause significant morbidity. Previous studies utilized whole genome and exome sequencing to identify a few somatic variants, but no recurrent mutations were ...
Jain S +4 more
europepmc +3 more sources
OTEH-1. Alternative RNA splicing modulates composition of ribosomes and determines spatial phenotype of glioblastoma cells [PDF]
Neurooncol Adv, 2021 Abstract Glioblastoma (GBM) is an extremely heterogeneous tumor and its different regions are populated with phenotypically distinct types of cancer cells. However, it is still unclear how multiple GBM populations arise from the originally homogenous group of tumor precursor cells.
Pavlyukov M +5 more
europepmc +3 more sources
OTEH-6. Algorithmic approach to characterize post-treatment recurrent glioma using RNA sequencing and quantitative histopathology [PDF]
Neurooncol Adv, 2021 Abstract Introduction Distinguishing between tumor and treatment effect in post-treatment glioma, although crucial for clinical management, is difficult because contrast-enhancing regions are mixtures of recurrent tumor and reactive tissue, and definitive histopathological criteria do not exist.
Argenziano M +11 more
europepmc +3 more sources
OTEH-5. Characterization of long-non coding RNA associated ceRNA network hub gene involved in glioblastoma multiforme lipid metabolism [PDF]
Neurooncol Adv, 2021 Abstract Background Glioblastoma multiforme (GBM) are the major death contributor in primary brain tumour. Despite having an improved diagnostic criterion by integrating both histological and molecular features such as Isocitrate Dehydrogenase (IDH) detection, the prognosis of GBM patients still ...
Rizalhanafi F +5 more
europepmc +3 more sources
OTEH-3. Targeted Gene-Expression analysis during malignant transformation in primary and secondary malignant meningioma [PDF]
Neurooncol Adv, 2021 Abstract Background Malignant meningiomas comprise 2–5% of all meningiomas. The process of malignant transformation when benign meningiomas (WHO grade I-II) become malignant (WHO grade III) has not previously been investigated in sequential tumour surgeries.
Maier A +17 more
europepmc +3 more sources
OTEH-9. scRNA sequencing of proneural GBM avatar model reveals acquisition of oncogenic transcriptional programming and infers a developmental path towards a genomically unstable state [PDF]
Neurooncol Adv, 2021 Abstract Glioblastomas (GBMs) are the most common malignant primary brain tumors, and the paucity of novel treatments warrants an investigation of its origins and development into aggressive, lethal tumors. Koga & Chaim et al. have recently shown that human pluripotent stem cells (hiPSCs) with different combinations of driver ...
Taylor B +6 more
europepmc +3 more sources
OTEH-2. High-dimensional analysis of spatial immune cell heterogeneity in glioblastoma reveals differences between contrast-enhancing and non-contrast-enhancing tumor rims [PDF]
Neurooncol Adv, 2021 Abstract Background Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. GBM remains an incurable disease, with a median survival ~20 months. Complex intercellular interactions within the tumor microenvironment and spatial heterogeneity have challenged and impeded therapeutic
Watson D +5 more
europepmc +3 more sources
Effects of Swedish massage therapy on blood pressure, heart rate, and inflammatory markers in hypertensive women. [PDF]
Evid Based Complement Alternat Med, 2013 Swedish Massage Therapy (SMT) is known for its therapeutic relaxation effects. Hypertension is associated with stress and elevated endothelial inflammatory markers. This randomized control trial measured the effects of whole body SMT (massage group) or resting (control group) an hour weekly for four weeks on hypertensive women.
Supa'at I +4 more
europepmc +2 more sources
Repeating stereotypes: Increased belief and subsequent discrimination
European Journal of Social Psychology, Volume 52, Issue 3, Page 528-537, April 2022., 2022 Abstract People believe repeated information more than novel information. Classic research on this repetition‐induced truth effect used trivia statements as information and truth ratings as the main DV. We investigate how repeating stereotypes about groups influence the stereotypes' believability and decisions about group members.
Esra Hatice Oğuz Taşbaş +1 more
wiley +1 more source
Coronary artery center-line extraction using second order local features. [PDF]
Comput Math Methods Med, 2012 Of interest is the accurate and robust delineation of vessel center‐lines for complete arterial tree structure in coronary angiograms which is an imperative step towards 3D reconstruction of coronary tree and feature‐based registration of multiple view angiograms.
Zamani Boroujeni F +4 more
europepmc +2 more sources