Results 81 to 90 of about 2,490,954 (252)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

On the Design of Virtual Reality Learning Environments in Engineering

open access: yesMultimodal Technologies and Interaction, 2017
Currently, the use of virtual reality (VR) is being widely applied in different fields, especially in computer science, engineering, and medicine. Concretely, the engineering applications based on VR cover approximately one half of the total number of VR
Diego Vergara   +2 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The Effect of Pluralistic Ignorance on Women's Interest in the STEM Fields_

open access: yesThe Owl, 2013
Although women earn 50% of all bachelor’s degrees in the United States, they earn less than 20% of computer science and engineering degrees. There is much research focusing on the lack of women in science, technology, engineering, and mathematics (STEM ...
Abigail Lynne Muldoon
doaj  

Auricular bioelectronic devices for health, medicine, and human-computer interfaces

open access: yesFrontiers in Electronics
Recent advances in manufacturing of flexible and conformable microelectronics have opened opportunities for health monitoring and disease treatment. Other material engineering advances, such as the development of conductive, skin-like hydrogels, liquid ...
William J. Tyler
doaj   +1 more source

Genetic tool development and systemic regulation in biosynthetic technology

open access: yesBiotechnology for Biofuels, 2018
With the increased development in research, innovation, and policy interest in recent years, biosynthetic technology has developed rapidly, which combines engineering, electronics, computer science, mathematics, and other disciplines based on classical ...
Zhongxue Dai   +7 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

COMPUTER GRAPHICS - ENGINEERING ANIMATION STUDY PROGRAM AT THE FACULTY OF TECHNICAL SCIENCES IN NOVI SAD

open access: yesJournal of Industrial Design and Engineering Graphics, 2019
Computer Graphics - Engineering Animation study program got certified at the Faculty of Technical Sciences in Novi Sad, University of Novi Sad, Serbia in December 2010. The study program consists of Undergraduate Academic Studies (UAS) that last 4 years (
Ratko Obradovic   +4 more
doaj   +4 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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