Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The Effect of Pluralistic Ignorance on Women's Interest in the STEM Fields_
The Owl, 2013 Although women earn 50% of all bachelor’s degrees in the United States, they earn less than 20% of computer science and engineering degrees. There is much research focusing on the lack of women in science, technology, engineering, and mathematics (STEM ...
Abigail Lynne Muldoon
doaj
On the Design of Virtual Reality Learning Environments in Engineering
Multimodal Technologies and Interaction, 2017 Currently, the use of virtual reality (VR) is being widely applied in different fields, especially in computer science, engineering, and medicine. Concretely, the engineering applications based on VR cover approximately one half of the total number of VR
Diego Vergara +2 more
doaj +1 more source
CAD, BIM, GIS and other tricks of the computer science in the education of the Building Engineer
, 2011 Revisione internazionale- relazione a invito- chair sessione S8T The paper aims to develop some thoughts on the upgrade implemented in the disciplines of drawing from the latest forms of digital representation, commenting on the experiences under way in some university courses included in the learning curriculum provided to engineering students with ...
NOVELLO, Giuseppa +1 more
openaire +1 more source
STICAP: A linear circuit analysis program with stiff systems capability. Volume 1: Theory manual [PDF]
STICAP (Stiff Circuit Analysis Program) is a FORTRAN 4 computer program written for the CDC-6400-6600 computer series and SCOPE 3.0 operating system. It provides the circuit analyst a tool for automatically computing the transient responses and frequency
Cooke, C. H.
core +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Genetic tool development and systemic regulation in biosynthetic technology
Biotechnology for Biofuels, 2018 With the increased development in research, innovation, and policy interest in recent years, biosynthetic technology has developed rapidly, which combines engineering, electronics, computer science, mathematics, and other disciplines based on classical ...
Zhongxue Dai +7 more
doaj +1 more source
Bayesian Subset Simulation: a kriging-based subset simulation algorithm for the estimation of small probabilities of failure [PDF]
, 2012 The estimation of small probabilities of failure from computer simulations is a classical problem in engineering, and the Subset Simulation algorithm proposed by Au & Beck (Prob. Eng.
Bect, Julien +2 more
core +2 more sources
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source