Results 111 to 120 of about 446,209 (289)
12th CIRP Conference on Computer Aided Tolerancing [PDF]
, 2011 The purpose of this paper is to decipher the process of modelling driving to the product behaviour simulation. A simple example of simulation, tolerance stackup, allows illustrating this process.
BALLU, Alex +2 more
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FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
, 2014 Designing complex engineering systems, such as an aircraft or an aero-engine, is immensely challenging. Formal Systems Engineering (SE) practices are widely used in the aerospace industry throughout the overall design process to minimise the overall ...
Eres, M.H. +8 more
core +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Neural Parameter-Space Classification And Applications to Hardware Explanation
Neural networks encode information into the parameters they learn during training. This thesis explores the use of machine learning techniques both to differentiate a single trained neural network from other similar networks and to identify the dataset ...
Clemens, John Michael
core +1 more source
Fundamentals of Structural Engineering
, 2013 Fundamentals of Structural Engineering provides a balanced, seamless treatment of both classic, analytic methods and contemporary, computer-based techniques for conceptualizing and designing a structure.
Connor, Jerome J, Faraji, Susan
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Renewable Energy Applications Across Engineering Disciplines: A Comprehensive Review
Applied SciencesRenewable energy technologies are becoming more and more relevant in a variety of engineering fields as a result of the move toward low-carbon, sustainable energy systems. Although research has historically concentrated on power generation, it now covers
Mustafa Sacid Endiz +8 more
doaj +1 more source
, 2004 Computer engineering as an academic field encompasses the broad areas of computer science and electrical engineering. Computer engineering is defined in this report as follows. Computer engineering is a discipline that embodies the science and technology
Cross, J. +9 more
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