Results 131 to 140 of about 9,021,901 (317)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Towards other education on knowledge society: pedagogical issues and proposals

open access: yesEducation in the Knowledge Society, 2013
his article aims to analyze, firstly, some key issues involved in “knowledge society” and “education in the knowledge society”. Thus, knowledge is the result of the attitude of seeking truth and error rejection.
Ramón MÍNGUEZ VALLEJOS   +1 more
doaj  

Science in the New Zealand Curriculum e-in-science [PDF]

open access: yes, 2012
This milestone report explores some innovative possibilities for e-in-science practice to enhance teacher capability and increase student engagement and achievement. In particular, this report gives insights into how e-learning might be harnessed to help
Buntting, Catherine Michelle   +4 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Preventing hot beverage scald injuries to young children [PDF]

open access: yes, 2003
The focus of the research proposal was two-fold: to analyse the emphasis placed on hot beverage scald injuries to under five year olds in current public education material for parents and caregivers; and to make practical recommendations in regard to ...
Dekrout, Heidimarie   +2 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

THE ROLE OF WORKING CLASS (OTHER WOMEN) IN CRITICAL EDUCATION

open access: yesEducation in the Knowledge Society, 2009
This article looks at the role and experiences of working class (other) womenwho return to education in universities and community education. The educational experiencesare explored through the voices of working class women by using feministbiographical ...
Barbara Merrill
doaj  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

An alternative technical education system : a case study of Mexico [PDF]

open access: yes
Many developing countries have relied on the varied forms of diversified secondary technical education as the main venue for training skilled workers and mid-level technicians.
Kye Woo Lee
core  

Becta review 2006. Evidence on the progress of ICT in education. [PDF]

open access: yes, 2006
This is the review of the use and impact of ICT in the education system prior to the publication of the Government's e-Strategy for the education system, known as Harnessing Technology.
Davies, Steve   +2 more
core  

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