Results 71 to 80 of about 9,021,901 (317)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Can simulation-based education or other education interventions replace clinical placement in medical radiation sciences? A narrative review. [PDF]

Radiography (Lond), 2023
Jimenez YA, Gray F, Di Michele L, Said S, Reed W, Kench P.   +5 more
europepmc   +1 more source

Measuring Up 2006: The National Report Card on Higher Education [PDF]

, 2006
Measures the performance of the U.S. and of each state in providing education and training beyond high school.
Garrey Carruthers, Patrick M. Callan, Peter T. Ewell   +2 more
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Efficacy and Safety of Mycobacterium indicus pranii as an adjunct therapy in Category II pulmonary tuberculosis in a randomized trial

Scientific Reports, 2017
Prolonged treatment of tuberculosis (TB) often leads to poor compliance, default and relapse, converting primary TB patients into category II TB (Cat IITB) cases, many of whom may convert to multi-drug resistant TB (MDR-TB).
Surendra K. Sharma, Kiran Katoch, Rohit Sarin, Raman Balambal, Nirmal Kumar Jain, Naresh Patel, Kolluri J. R. Murthy, Neeta Singla, P. K. Saha, Ashwani Khanna, Urvashi Singh, Sanjiv Kumar, A. Sengupta, J. N. Banavaliker, D. S. Chauhan, Shailendra Sachan, Mohammad Wasim, Sanjay Tripathi, Nilesh Dutt, Nitin Jain, Nalin Joshi, Sita Ram Raju Penmesta, Sumanlatha Gaddam, Sanjay Gupta, Bakulesh Khamar, Bindu Dey, Dipendra K. Mitra, Sunil K. Arora, Sangeeta Bhaskar, Rajni Rani   +29 more
doaj   +1 more source

Circular 02/05 : quality and standards : reviewing performance : arrangements for colleges and other providers [PDF]

, 2002
"This consultation circular is addressed to Learning and Skills Council (Council) funded colleges, Ufi hubs and other providers, including those delivering further education, work-based learning, adult and community learning, information, advice and ...

core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Learning factors influencing second language proficiency: a cross-cultural comparative study of English and Chinese L2 learners

BMC Psychology
Background Globalization has spurred a rise in second language (L2) learners, necessitating deeper understanding of psychological and cognitive factors shaping their learning processes.
Xuancheng Wu, Xin Wen, Juan Lu, Weizhi Liu   +3 more
doaj   +1 more source

On a shoestring: child speakers of other languages in Slovak education

Journal of Language and Cultural Education, 2020
This article focuses on children who cannot speak the language of the majority when they enter the school system. It recommends that the term child speakers of other languages should be adopted in Slovakia. Various approaches and types of support used in
Bánovčanová Zuzana, Danišková Zuzana, Filagová Markéta   +2 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source