Results 71 to 80 of about 410,017 (332)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
A metric profile of research highlighting teacher training in Science Education in Brazil
Investigações em Ensino de Ciências, 2019 This paper focuses on what current literature indicates about the need to learn about the teacher training research field in a wide-ranging and profound manner. Within this framework, the objective was to outline a metric profile of the research field of
Julio César Castilho Razera +2 more
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Editorial: Entrepreneurship Education
Horyzonty Wychowania, 2014 Education plays a key role in shaping the attitudes, skills and culture, hence the actions of the European Union in recent years have aimed at promoting entrepreneurship as a separate course taught at all levels of education, from elementary up to the ...
Krzysztof Wach
doaj
Features of Simulation-Based Educational Programs: Example of Transport Education and Training
Современные информационные технологии и IT-образование, 2019 The introduction of high technology results in growing demand for practical skills that constitute inherent part of employees’ qualifications acquired through on-the-job training as well as during education period.
Alexander A. Klimov +2 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Open Educational Resources in Higher Education
Issues and Trends in Educational Technology, 2018 Open Educational Resources (OERs) are changing the learning and teaching landscape in many different fields. In the area of higher education, OERs are swiftly becoming important elements in support of Open Educational Practices (OEPs) and the Open ...
Margherita Berti
doaj +2 more sources
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Social Work and Society, 2011 An economization of many social fields in Germany and other countries is under way, such as in the arts, journalism, education and science. Economic considerations have the upper hand in academic education (e.g., the introduction of tuition fees), while ...
Ursula H. Werling
doaj +2 more sources
Legal Education And Challenges Of Contemporary Developments In Nigeria
International Journal of Clinical Legal Education, 2014 The development of any society is anchored on the existence of enabling environment for imparting legal education. Technological breakthrough and globalization among other things has made the provision of sound legal education to would-be lawyers and ...
Bagoni Bukar
doaj +1 more source