Results 61 to 70 of about 2,550,298 (280)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Comparative Analysis of Sparse Matrix Algorithms For Information Retrieval [PDF]

Journal of Systemics, Cybernetics and Informatics, 2003
We evaluate and compare the storage efficiency of different sparse matrix storage formats as index structure for text collection and their corresponding sparse matrixvector multiplication algorithm to perform query processing in information retrieval (IR)
Nazli Goharian, Ankit Jain, Qian Sun
doaj  

Pole placement with minimum gain and sparse static feedback [PDF]

E3S Web of Conferences
The work addresses the issue of developing polar positioning algorithms for linear control systems with despotic thinning constraints on a static feedback matrix.
Sevinov Jasur, Kadirov Yorkin, Boeva Okila, Boybutaev Sanjar, Rasulov Abdikhoshim   +4 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Speech Enhancement Control Design Algorithm for Dual-Microphone Systems Using β-NMF in a Complex Environment

Complexity, 2018
Single-microphone speech enhancement algorithms by using nonnegative matrix factorization can only utilize the temporal and spectral diversity of the received signal, making the performance of the noise suppression degrade rapidly in a complex ...
Dong-xia Wang, Mao-song Jiang, Fang-lin Niu, Yu-dong Cao, Cheng-xu Zhou   +4 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Enhanced Community Detection via Convolutional Neural Network: A Modified Approach Based on MRFasGCN Algorithm

IEEE Access
Community detection is a very important research topic in the field of Social Network Analysis. Lots of researchers are working in this field due to its applications in various fields like medicine, social, Business, Marketing, and research.
Puneet Kumar, Dalwinder Singh, Mamoona Humayun, Ali Alqazzaz, Arun Malik, Ibrahim Alrashdi, Isha Batra, Ghadah Naif Alwakid   +7 more
doaj   +1 more source

Energy-Based Adaptive CUR Matrix Decomposition

IEEE Access, 2023
CUR decompositions are interpretable data analysis tools that express a data matrix in terms of a small number of actual columns and/or actual rows of the data matrix.
Liwen Xu, Xuejiao Zhao, Yongxia Zhang
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

A Hybrid Algorithm for Estimating Origin-Destination Flows

IEEE Access, 2018
With the development of intelligent transportation systems, the estimation of traffic flow in urban areas has attracted a great attention of researchers.
Xianghua Li, Jurgen Kurths, Chao Gao, Junwei Zhang, Zhen Wang, Zili Zhang   +5 more
doaj   +1 more source