Results 31 to 40 of about 244,159 (188)
Divisor class groups of rational trinomial varieties
, 2019 We give an explicit description of the divisor class groups of rational trinomial varieties. As an application, we relate the iteration of Cox rings of any rational variety with torus action of complexity one to that of a Du Val surface.Comment: 17 ...
Arzhantsev +17 more
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Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Introduction to Sofic and Hyperlinear groups and Connes' embedding conjecture
, 2015 Sofic and hyperlinear groups are the countable discrete groups that can be approximated in a suitable sense by finite symmetric groups and groups of unitary matrices.
Capraro, Valerio, Lupini, Martino
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Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Locally finite profinite rings
, 2013 We investigate the structure of locally finite profinite rings. We classify (Jacobson-) semisimple locally finite profinite rings as products of complete matrix rings of bounded cardinality over finite fields, and we prove that the Jacobson radical of ...
Dobrowolski, Jan, Krupiński, Krzysztof
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
VIC-modules over noncommutative rings
, 2020 For a finite ring $R$, not necessarily commutative, we prove that the category of $\text{VIC}(R)$-modules over a left Noetherian ring $\mathbf{k}$ is locally Noetherian, generalizing a theorem of the authors that dealt with commutative $R$.
Putman, Andrew, Sam, Steven V
core