Results 121 to 130 of about 490,864 (295)
آموزش مهندسی ایرانThe mechanical engineering curriculum, at both the undergraduate and postgraduate levels, has been revised twice in the last decade. Despite these updates, its core foundation remains based on older models.
Jafar Ghazanfarian
doaj +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Mechanical characterization of a melt-drawn Poly(L-lactide-co-ε-caprolactone) (PLC) for tissue engineering application [PDF]
, 2016 This report outlines the student’s project to investigate the mechanical properties of melt-drawn POLY(L-lactide-co--caprolactone) (PLC) of 90-10 composition used in tissue engineering. It is a type of semicrystalline co-polymer.
Goh, Wei Jian
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Developing inquiry-based laboratory exercises for a mechanical engineering curriculum [PDF]
, 2012 This paper describes the development of two inquiry-based experiments in a mechanical engineering curriculum at a land grant research-intensive university, aimed at providing students with the opportunity to design and perform experiments. One experiment
Meyer, Terrence +2 more
core +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
The Pressure Losses in 90° Bends of Rectangular Cross-section [PDF]
, 1966 An experimental study of turbulent flow of air around a 90º bend is reported in this thesis. Four 90º bends of aspect ratio 1, 3, 5 & 10 and radius ratio 1.0 have been tested in the Reynolds number range of 1 × 10⁵ to 5 × 10⁵. The loss in total pressure
Kacker, Suresh Chandra
core
Magnetic Substrates for Tissue Engineering—A Review
MagnetochemistryTissue engineering is based on combining cells with suitable scaffolds and growth factors. Recently, bone tissue engineering has been especially investigated deeply due to a large number of bone-related diseases.
Tomasz Blachowicz, Andrea Ehrmann
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Multi-objective Optimization-Driven Design: Generative Design Approach for Manufacturing of a Train Bogie [PDF]
In recent years, advances in additive manufacturing (AM) technologies, particularly in Direct Energy Deposition (DED) as Wire Arc Additive Manufacturing (WAAM) and Laser Wire Directed Energy Deposition (LW-DED), have enabled engineers to produce large ...
Asadi, Reza +4 more
core +1 more source