Results 131 to 140 of about 1,856,164 (287)
Collaborative research in cardiovascular dynamics and bone elasticity [PDF]
A collaborative research program covering a variety of topics of biomechanics and biomedical engineering within the fields of cardiovascular dynamics, respiration, bone elasticity and vestibular physiology is described.
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Agglomeration economies, knowledge spillovers, technological diversity and spatial clustering of innovations. [PDF]
This paper explores the spatial patterns of innovative activities from an empirical perspective and with reference to the Italian case. Using patent and other economic data at the NUTS 3 level (provinces), it borrows methodology and techniques from ...
Stefano Breschi
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Competition and cooperation in a metal engineering production system [PDF]
In the discussion on the prospects for growth of the manufacturing system in Italy one still unsolved problem stands out: the small size of the firms. There is a great concern regarding not only sectors facing strong competition from countries with a low
Elena Pirani, Margherita Russo
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The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Design of a mechanical teaching vehicle controlled by cam structure
Discover Applied SciencesThis paper addresses the challenges of weak correlation in wheel train mechanism learning, incomplete cam design training steps, and restricted industrial software combination learning in conventional mechanical manufacturing courses.
Guanghong Xin +4 more
doaj +1 more source
Mundo FescThis work is the investigative consequence of artificial intelligence and its collaboration with mechanical, industrial, and metallurgical engineering, which is experiencing exponential growth.
Francisco Raúl Arencibia Pardo +2 more
doaj +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source