Results 51 to 60 of about 1,867,674 (286)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Assessment of Mechanical Engineering Research Output using Scientometric Indicators: A Comparative Study of India, Japan, and South Korea

open access: yesJournal of Information Science Theory and Practice, 2017
This study examined the mechanical engineering research output from India, Japan, and South Korea on different parameters including growth, collaboration indices, and activity index.
Pattanashetti, D.M., Harinarayana, N.S.
doaj   +1 more source

Normalizing the Microenvironment Overcomes Vessel Compression and Resistance to Nano‐immunotherapy in Breast Cancer Lung Metastasis

open access: yesAdvanced Science, 2021
Nano‐immunotherapy regimens have high potential to improve patient outcomes, as already demonstrated in advanced triple negative breast cancer with nanoparticle albumin‐bound paclitaxel and the immune checkpoint blocker (ICB) atezolizumab.
Fotios Mpekris   +18 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

The status of technology development in Iran with a look at the condition of mechanical engineering

open access: yesآموزش مهندسی ایران, 2020
Today, technology development is not only a straight forward approach to create wealth, but is a means for superiority of countries in military, industry and economy.
Alli Ghafari   +1 more
doaj   +1 more source

Reformulation of the Integrated Master in Mechanical Engineering (MIEM) at FEUP in Two Cycles of Studies (Bachelor and Master)

open access: yesU.Porto Journal of Engineering, 2021
This paper presents the reformulation of the Integrated Master in Mechanical Engineering (MIEM) at the Faculty of Engineering of the University of Porto (FEUP) in two independent degrees (bachelor and master).
Lucas da Silva   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Stochastic Resonance Can Drive Adaptive Physiological Processes [PDF]

open access: yes, 2009
Stochastic resonance (SR) is a concept from the physics and engineering communities that has applicability to both systems physiology and other living systems. In this paper, it will be argued that stochastic resonance plays a role in driving behavior in
Bradly J. Alicea
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

A Damaged Constitutive Model for Rock under Dynamic and High Stress State

open access: yesShock and Vibration, 2017
The main research work of this paper focuses on the theoretical prediction of the constitutive relationship for rock, concrete, and other quasi-brittle materials under dynamic and complex stress state and the influence of dynamic mechanical behavior of ...
Yan-Long Li, Zong-Yuan Ma
doaj   +1 more source

Home - About - Disclaimer - Privacy