Results 81 to 90 of about 1,856,164 (287)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Acta PsychologicaThe study was conducted on engineering students pursuing a B.Tech. in Civil and Mechanical engineering. The study involves a Mixed Method Design. A stratified sampling technique was used to collect the data from the sample subjects (Students), and for ...
Syed Inshaallah Tahir, Tasleema Jan
doaj +1 more source
INTEGRATED SCIENTIFIC-MANUFACTURING COMPLEXES AS A BASIS OF MODERN MECHANICAL ENGINEERING [PDF]
Экономика региона, 2007 The experience of FGUP PO "Uralvagonzavod" development is shown in the article, the analysis of mechanical engineering development in our country on modern stage is given.
N.A. Malyh
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
PRODUCT DESIGN TECHNIQUES IN AUTOMOTIVE PRODUCTION [PDF]
Applied Computer Science, 2012 In the present and medium term perspective in the future, the mechanical engineering and other industrial branches are facing advanced challenges arising from global changes in the technical, economic and social environment.
Michal DÚBRAVČÍK +2 more
doaj
Technical feasibility study for the development of a large capacity wind powered electrical generating system [PDF]
The engineering feasibility of developing a basic mechanical system necessary for extracting large amounts of power (on the order of 10 to 20 MW) from the wind is considered using the concept of vertical airfoils moving along a closed horizontal track ...
Powe, R. E.
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Mechanical Engineering: Medium-Sized Companies with Highest Savings Potential
, 2010 The German mechanical engineering industry, dominated by medium-sized companies, is greatly successful - both on the domestic and on the international market.
Kritikos, Alexander S. +1 more
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source