Results 151 to 160 of about 4,774,812 (307)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The Readiness For Interprofessional Education (IPE) In The School Setting Among The Internship Students Of Applied Medical Sciences At Taibah University

Advances in Medical Education and Practice, 2019
Suliman Salih,1,2 Moawia Gameraddin,1,3 Sameer Kamal,4 Mohamed Alsadi,1 Jumaa Tamboul,1 Kamal Alsultan1 1Faculty of Applied Medical Sciences, Taibah University, Medina, Saudi Arabia; 2National Cancer Institute, University of Gezira, Wad Madani, Sudan ...
Salih S, Gameraddin M, Kamal S, Alsadi M, Tamboul J, Alsultan K   +5 more
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Association between serum zinc and copper levels and antioxidant defense in subjects infected with human T-lymphotropic virus type 1

Journal of Blood Medicine, 2018
Samaneh Abolbashari,1,* Susan Darroudi,1,* Maryam Tayefi,2,3 Zahra Khashyarmaneh,4 Parvin Zamani,5 Hamideh Moalemzadeh Haghighi,4 Amir Hooshang Mohammadpour,6,7 Shima Tavalaei,8 Mahsa Ahmadnezhad,9 Habibollah Esmaily,10 Gordon A Ferns,11 Zahra Meshkat,12
Abolbashari S, Darroudi S, Tayefi M, Khashyarmaneh Z, Zamani P, Moalemzadeh Haghighi H, Mohammadpour AH, Tavalaei S, Ahmadnezhad M, Esmaily H, Ferns GA, Meshkat Z, Ghayour-Mobarhan M   +12 more
doaj  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Studying Job Involvement And Its Relation With Other Variables Among Non-Faculty Staff Of Iranian Universities Of Medical Sciences: A Review

, 2018
Introduction: Considering the effective role of job involvement in increasing organizational effectiveness, this research has been done to investigate job involvement and its relation with other variables among non-faculty staff of Iranian universities of medical sciences. Materials and Methods: This has been done as a simple overview in 2018. Research
openaire   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Predictors of carotenoid status in New Zealand children using carotenoid reflection score: a cross-sectional study. [PDF]

Asia Pac J Clin Nutr
Rapson J, Rush E, McLean R, Fuavao K, Wall C, Eyles H.   +5 more
europepmc   +1 more source