Results 231 to 240 of about 1,990,739 (252)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

A four-step implementation framework for professionalism competency in undergraduate medical education. [PDF]

Front Med (Lausanne)
Farooq M, Ljubisavljevic MR, Eldin Magzoub M, Al Marzooqi S, Younis T.   +4 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Strategies for integrating artificial intelligence and cognitive assessment to predict disability progression in relapsing-remitting multiple sclerosis: A model development study. [PDF]

PLOS Digit Health
Zhu C, Zhang X, van der Walt A, Taylor B, Monif M, Kalincik T, Lechner-Scott J, Buzzard K, Kilpatrick T, Barnett M, Zhou Z, Jokubaitis V, Gresle M, Darby D, Mehta D, Ge Z, Butzkueven H, Merlo D.   +17 more
europepmc   +1 more source

Scaling-up tuberculosis preventive therapy to HIV-negative contacts of bacteriologically confirmed TB cases aged 5 years and above - Lessons from a tuberculosis preventive therapy surge activity in Zambia. [PDF]

PLOS Glob Public Health
Mwaba PB, Mwaba I, Maimbolwa MM, Chanda C, Mputu M, Lumbwe C, Zimba K, Chanda NK, Chimzizi R, Mubanga A, Muyoyeta M, Kagujje M.   +11 more
europepmc   +1 more source

Sandhoff Disease Associated With Bipolar Disorder: A Case Report From the United Arab Emirates. [PDF]

Cureus
Abdelrahman A, Alowais M, Elamin A, Ahmed AE, Rakhange A, Darweesh A, Adi AJ, Otour A.   +7 more
europepmc   +1 more source

Modifiable predictors of atrioventricular block warranting a pacemaker: A cohort study. [PDF]

PLoS One
Thein AS, Tang JJ, Noubiap JJ, Dewland TA, Biering-Sørensen T, Marcus GM.   +5 more
europepmc   +1 more source

Among individuals who die of COVID-19, is the percentage who had diabetes actually higher than in those dying of other viral infections? [PDF]

Cardiovasc Diabetol Endocrinol Rep
Reddy NV, Pate V, Stürmer T, Wong R, Harper J, Reusch JE, Wilkins KJ, Tronieri J, Buse JB, Johnson SG, Bramante CT.   +10 more
europepmc   +1 more source

Correction to "A Randomized Controlled Trial With an Internal Pilot of a Co-Designed App Targeting Upstream Suicide-Related Risk and Protective Factors Among International Students". [PDF]

Suicide Life Threat Behav
europepmc   +1 more source