Results 211 to 220 of about 1,897,569 (274)

Maternal oxidative stress biomarkers across pregnancy in relation to fetal growth: evidence from the TIDES cohort. [PDF]

Am J Epidemiol
Baghsheikhi H, Trasande L, Manuel RSJ, Shahin S, Cajachagua-Torres KN, Duh-Leong C, Kannan K, Barrett ES, Bush NR, Nguyen RH, Swan SH, Sathyanarayana S, Stevens D, Ferguson KK, Cowell W.   +14 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Characterizing acute and persistent symptoms of COVID-19 among adults and children in rural Zambia, 2020-2022. [PDF]

PLOS Glob Public Health
Sutcliffe CG, Sinywimaanzi P, Hamahuwa M, Morales J, van de Guchte A, Sianyanda M, Khalil Z, Munachoonga P, Gonzalez-Reiche AS, Muleka M, Fenstermacher KZJ, Monze M, van Bakel H, Rothman RE, Pekosz A, Simulundu E.   +15 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Healthcare providers' perspectives on integrating trauma-informed care for intimate partner violence in HIV/STI clinical settings in Trinidad and Tobago. [PDF]

PLOS Glob Public Health
Lyons N, Olivier M, Samaroo-Francis W, Seeram I, Bhagwandeen B, Edwards J.   +5 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Corrigendum to 'The association between quality of life, anxiety and depression, and residual limb and phantom limb pain in war-related amputees: a year-long observational study' eClinicalMedicine 2026;▪: 103891 (in press). [PDF]

EClinicalMedicine
Smolynets R, Barroso J, Pasquina PF, Cohen SP.   +3 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Elevated high sensitivity cardiac troponin T among men with HIV who use stimulants: A cross-sectional study of subclinical cardiovascular injury. [PDF]

PLoS One
Larson ME, Pan Y, Reidy L, Cherenack EM, Hirshfield S, Horvath KJ, Riley ED, Pahwa S, Pallikkuth S, Martinez C, Carrico AW.   +10 more
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source