Results 11 to 20 of about 4,881 (111)

Structure-Response Relationships in Rigid C₂-Symmetric Excitonic Systems: Principles, Modulation, and Functional Design Strategies. [PDF]

Chemphyschem
Rigid C2‐symmetric chromophores reveal how transition dipole orientation, magnitude, and conformational locking govern exciton coupling and g‐factor amplification, providing a structural blueprint for the rational design of advanced chiroptical molecular and material architectures.
Gómez-Oya I, Portela-Pino J, Ozcelik A, Alonso-Gómez JL.   +3 more
europepmc   +2 more sources

The Use of Botulinum Toxin Injections in Peripheral Neuropathic Pain: A Systematic Review of Efficacy and Safety Outcomes. [PDF]

Pain Res Manag
Peripheral neuropathic pain (PNP), a chronic condition resulting from nerve damage and characterized by altered sensory signaling and central sensitization, poses significant therapeutic challenges. Botulinum toxin (BTX), known for neuromuscular blockades, also exhibits analgesic properties, prompting its investigation for PNP management.
Restivo DA, Calderone A, Quartarone A, Calabrò RS, Bruschetta A.   +4 more
europepmc   +2 more sources

Harnessing Phenonium Ions in Synthesis. [PDF]

Angew Chem Int Ed Engl
Phenonium ions have frequently been viewed as intermediates of theoretical interest, but whose synthetic utility was limited. This minireview outlines how physical‐organic characterization has led to a better understanding of controlling their formation, which has resulted in modern strategies to form phenonium ions straightforwardly and use them in a ...
Mayer RJ, Lebœuf D.
europepmc   +3 more sources

Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting. [PDF]

CNS Neurosci Ther
Pyroptosis is a key inflammatory cell death pathway in peripheral neuropathy, with opposing roles: it perpetuates neuropathic pain but can be induced to kill neuroblastoma cells. This review consolidates mechanistic understanding and therapeutic strategies, arguing for a shift from disease‐centric to target‐centric treatment approaches to improve ...
Wei J, Liuyuan M, Ye Z, Wang X, Zhou X, Shan Y, He C, Zhu C, Zhou C, Bao J, Zhang Y, Chen G.   +11 more
europepmc   +2 more sources

Tumor-Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation. [PDF]

MedComm (2020)
Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Bao W, Qu X, Wang Y, Huang D, Zhang H, Dong M, Sun H, Yang Z, Li X.   +8 more
europepmc   +2 more sources

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Phase Separation of Nucleic Acids: Mechanisms, Properties, and Applications

Angewandte Chemie International Edition, EarlyView.
Recent discoveries have shown that single‐stranded long‐chain nucleic acids can undergo temperature‐induced phase separation, enabling formation of micrometer‐sized condensates. This Minireview discusses the current mechanistic understanding of this phenomenon, highlights strategies for controlling the physical and chemical properties of these ...
Weixiang Chen, Johann Fritzen, Andreas Walther   +2 more
wiley   +1 more source

Engineering superpositions of displaced number states of a trapped ion

, 2004
We present a protocol that permits the generation of a subtle with superposition with 2^(l+1) displaced number states on a circle in phase space as target state for the center-of-mass motion of a trapped ion.
An, Budini, Budini, Carmichael, Chountasis, Chountasis, Cirac, Davidovich, de Matos Filho, de Matos Filho, de Oliveira, Dodonov, Feng, Feng, Gardiner, Gerry, Huyet, Itano, Jonathan, José, Kis, Lebedev, Leibfried, Leibfried, Lvovsky, Man'ko, Marchiolli, Meekhof, Monroe, Monroe, Monroe, Moya-Cessa, Myatt, Niukkanen, Plebański, Poyatos, Sackett, Schneider, Semião, Serra, Silva, Turchette, Turchette, Wallentowitz, Watson, Wineland, Zheng, Zheng   +47 more
core   +1 more source

On the Concept of a Notational Variant [PDF]

, 2017
In the study of modal and nonclassical logics, translations have frequently been employed as a way of measuring the inferential capabilities of a logic.
C Caleiro, E Jeřábek, FJ Pelletier, H Andréka, K Gödel, K Gödel, L Straßburger, M Kracht, P Blackburn, R Wójcicki, RL Epstein, SK Thomason, SK Thomason, T Mossakowski, WA Carnielli   +14 more
core   +1 more source

Quantum Correlations and Global Coherence in Distributed Quantum Computing

, 2018
Deviations from classical physics when distant quantum systems become correlated are interesting both fundamentally and operationally. There exist situations where the correlations enable collaborative tasks that are impossible within the classical ...
Lund, Austin P., Ralph, Timothy C., Shahandeh, Farid   +2 more
core   +1 more source