Results 11 to 20 of about 4,871 (111)

Cytokine-Engineered Chimeric Antigen Receptor-T Cell Therapy: How to Balance the Efficacy and Toxicity. [PDF]

Adv Sci (Weinh)
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Zhang X, Aimaiti G, Guan Y, Sha Y, Zhou W, Shen J, Zhao B, Yuan WE.   +7 more
europepmc   +2 more sources

Structure-Response Relationships in Rigid C₂-Symmetric Excitonic Systems: Principles, Modulation, and Functional Design Strategies. [PDF]

Chemphyschem
Rigid C2‐symmetric chromophores reveal how transition dipole orientation, magnitude, and conformational locking govern exciton coupling and g‐factor amplification, providing a structural blueprint for the rational design of advanced chiroptical molecular and material architectures.
Gómez-Oya I, Portela-Pino J, Ozcelik A, Alonso-Gómez JL.   +3 more
europepmc   +2 more sources

The Use of Botulinum Toxin Injections in Peripheral Neuropathic Pain: A Systematic Review of Efficacy and Safety Outcomes. [PDF]

Pain Res Manag
Peripheral neuropathic pain (PNP), a chronic condition resulting from nerve damage and characterized by altered sensory signaling and central sensitization, poses significant therapeutic challenges. Botulinum toxin (BTX), known for neuromuscular blockades, also exhibits analgesic properties, prompting its investigation for PNP management.
Restivo DA, Calderone A, Quartarone A, Calabrò RS, Bruschetta A.   +4 more
europepmc   +2 more sources

Phase Separation of Nucleic Acids: Mechanisms, Properties, and Applications. [PDF]

Angew Chem Int Ed Engl
Recent discoveries have shown that single‐stranded long‐chain nucleic acids can undergo temperature‐induced phase separation, enabling formation of micrometer‐sized condensates. This Minireview discusses the current mechanistic understanding of this phenomenon, highlights strategies for controlling the physical and chemical properties of these ...
Chen W, Fritzen J, Walther A.
europepmc   +2 more sources

Harnessing Phenonium Ions in Synthesis. [PDF]

Angew Chem Int Ed Engl
Phenonium ions have frequently been viewed as intermediates of theoretical interest, but whose synthetic utility was limited. This minireview outlines how physical‐organic characterization has led to a better understanding of controlling their formation, which has resulted in modern strategies to form phenonium ions straightforwardly and use them in a ...
Mayer RJ, Lebœuf D.
europepmc   +3 more sources

Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting. [PDF]

CNS Neurosci Ther
Pyroptosis is a key inflammatory cell death pathway in peripheral neuropathy, with opposing roles: it perpetuates neuropathic pain but can be induced to kill neuroblastoma cells. This review consolidates mechanistic understanding and therapeutic strategies, arguing for a shift from disease‐centric to target‐centric treatment approaches to improve ...
Wei J, Liuyuan M, Ye Z, Wang X, Zhou X, Shan Y, He C, Zhu C, Zhou C, Bao J, Zhang Y, Chen G.   +11 more
europepmc   +2 more sources

PHILOSOPHICAL AND SOCIOCULTURAL DIMENSIONS OF PERSONALITY PSYCHOLOGICAL SECURITY

Antropologìčnì Vimìri Fìlosofsʹkih Doslìdžen', 2018
Purpose. The dynamics and pace of social and economic transformations that are characteristic of modern society, lead to an increase in tension and the destruction of habitual stereotypes – ideals, values, norms, patterns of behaviour that unite people ...
O. Y. Blynova, L. S. Holovkova, O. V. Sheviakov   +2 more
doaj   +1 more source

A recovery operator for non-transitive approaches [PDF]

, 2018
In some recent articles, Cobreros, Egré, Ripley, & van Rooij have defended the idea that abandoning transitivity may lead to a solution to the trouble caused by semantic paradoxes.
Barrio, Eduardo Alejandro, Pailos, Federico Matias, Szmuc, Damián Enrique   +2 more
core   +1 more source

Iterated reflection principles over full disquotational truth [PDF]

, 2017
Iterated reflection principles have been employed extensively to unfold epistemic commitments that are incurred by accepting a mathematical theory. Recently this has been applied to theories of truth.
Fischer, Martin, Horsten, Leon, Nicolai, Carlo   +2 more
core   +3 more sources

Uncertainty relations and possible experience [PDF]

, 2016
The uncertainty principle can be understood as a condition of joint indeterminacy of classes of properties in quantum theory. The mathematical expressions most closely associated with this principle have been the uncertainty relations, various ...
Jaeger, Gregg
core   +2 more sources