Results 11 to 20 of about 4,879 (106)

Innate Immunity and Microbial Recognition in Reproduction: From Barrier Defense to Maternal-Fetal Tolerance. [PDF]

FASEB J
Graphical abstract illustrating the barrier defense–tolerance framework of reproductive innate immunity. Across the female and male reproductive tracts and the maternal–fetal interface, epithelial barriers, innate sensors, immune cells, and microbial signals are integrated to preserve reproductive homeostasis.
Rao X, Zou L, Yao Y, Liu C.
europepmc   +2 more sources

Cytokine-Engineered Chimeric Antigen Receptor-T Cell Therapy: How to Balance the Efficacy and Toxicity. [PDF]

Adv Sci (Weinh)
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Zhang X, Aimaiti G, Guan Y, Sha Y, Zhou W, Shen J, Zhao B, Yuan WE.   +7 more
europepmc   +2 more sources

The Roles of Macrophage Lineage Cells (MLCs) in Brain Aging. [PDF]

CNS Neurosci Ther
This review highlights the critical role of macrophage lineage cells (MLCs), including microglia, border‐associated macrophages (BAMs), and CNS‐infiltrating monocyte‐derived macrophages (MDMs), in brain aging. It explores the drivers and propagation of MLCs senescence and discusses potential therapeutic strategies targeting MLCs senescence.
Qin Q, Zhang L, Guo M, Lu D, Liu Y, Wang Z, Hu M, Wang S, Kang X, Yi H, Qiu W, Lu Z, Cai W.   +12 more
europepmc   +2 more sources

Structure-Response Relationships in Rigid C₂-Symmetric Excitonic Systems: Principles, Modulation, and Functional Design Strategies. [PDF]

Chemphyschem
Rigid C2‐symmetric chromophores reveal how transition dipole orientation, magnitude, and conformational locking govern exciton coupling and g‐factor amplification, providing a structural blueprint for the rational design of advanced chiroptical molecular and material architectures.
Gómez-Oya I, Portela-Pino J, Ozcelik A, Alonso-Gómez JL.   +3 more
europepmc   +2 more sources

Phase Separation of Nucleic Acids: Mechanisms, Properties, and Applications. [PDF]

Angew Chem Int Ed Engl
Recent discoveries have shown that single‐stranded long‐chain nucleic acids can undergo temperature‐induced phase separation, enabling formation of micrometer‐sized condensates. This Minireview discusses the current mechanistic understanding of this phenomenon, highlights strategies for controlling the physical and chemical properties of these ...
Chen W, Fritzen J, Walther A.
europepmc   +2 more sources

The Use of Botulinum Toxin Injections in Peripheral Neuropathic Pain: A Systematic Review of Efficacy and Safety Outcomes. [PDF]

Pain Res Manag
Peripheral neuropathic pain (PNP), a chronic condition resulting from nerve damage and characterized by altered sensory signaling and central sensitization, poses significant therapeutic challenges. Botulinum toxin (BTX), known for neuromuscular blockades, also exhibits analgesic properties, prompting its investigation for PNP management.
Restivo DA, Calderone A, Quartarone A, Calabrò RS, Bruschetta A.   +4 more
europepmc   +2 more sources

Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting. [PDF]

CNS Neurosci Ther
Pyroptosis is a key inflammatory cell death pathway in peripheral neuropathy, with opposing roles: it perpetuates neuropathic pain but can be induced to kill neuroblastoma cells. This review consolidates mechanistic understanding and therapeutic strategies, arguing for a shift from disease‐centric to target‐centric treatment approaches to improve ...
Wei J, Liuyuan M, Ye Z, Wang X, Zhou X, Shan Y, He C, Zhu C, Zhou C, Bao J, Zhang Y, Chen G.   +11 more
europepmc   +2 more sources

Tumor-Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation. [PDF]

MedComm (2020)
Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Bao W, Qu X, Wang Y, Huang D, Zhang H, Dong M, Sun H, Yang Z, Li X.   +8 more
europepmc   +2 more sources

Quantifiers for a Modal Future

Philosophical Perspectives, EarlyView.
ABSTRACT Future auxiliaries present a challenge to the classical analysis of modal expressions as existential or universal quantifiers over a contextually provided set of possible worlds: these expressions come with a distinct modal flavor, but their interaction with negation and the fact that future judgments come in degrees of confidence is ...
Malte Willer
wiley   +1 more source

On Counterfactuals and Contextuality

, 2004
Counterfactual reasoning and contextuality is defined and critically evaluated with regard to its nonempirical content. To this end, a uniqueness property of states, explosion views and link observables are introduced. If only a single context associated
Svozil, Karl
core   +4 more sources