Results 11 to 20 of about 426 (131)

Innate Immunity and Microbial Recognition in Reproduction: From Barrier Defense to Maternal-Fetal Tolerance. [PDF]

FASEB J
Graphical abstract illustrating the barrier defense–tolerance framework of reproductive innate immunity. Across the female and male reproductive tracts and the maternal–fetal interface, epithelial barriers, innate sensors, immune cells, and microbial signals are integrated to preserve reproductive homeostasis.
Rao X, Zou L, Yao Y, Liu C.
europepmc   +2 more sources

Cytokine-Engineered Chimeric Antigen Receptor-T Cell Therapy: How to Balance the Efficacy and Toxicity. [PDF]

Adv Sci (Weinh)
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Zhang X, Aimaiti G, Guan Y, Sha Y, Zhou W, Shen J, Zhao B, Yuan WE.   +7 more
europepmc   +2 more sources

The Dream of Recapture [PDF]

, 2022
As a response to the semantic and logical paradoxes, theorists often reject some principles of classical logic. However, classical logic is entangled with mathematics, and giving up mathematics is too high a price to pay, even for nonclassical theorists.
Nicolai, Carlo; id_orcid
core   +1 more source

Disagreement about logic [PDF]

, 2019
What do we disagree about when we disagree about logic? On the face of it, classical and nonclassical logicians disagree about the laws of logic and the nature of logical properties. Yet, sometimes the parties are accused of talking past each other.
Hjortland, Ole Thomassen
core   +1 more source

The Roles of Macrophage Lineage Cells (MLCs) in Brain Aging. [PDF]

CNS Neurosci Ther
This review highlights the critical role of macrophage lineage cells (MLCs), including microglia, border‐associated macrophages (BAMs), and CNS‐infiltrating monocyte‐derived macrophages (MDMs), in brain aging. It explores the drivers and propagation of MLCs senescence and discusses potential therapeutic strategies targeting MLCs senescence.
Qin Q, Zhang L, Guo M, Lu D, Liu Y, Wang Z, Hu M, Wang S, Kang X, Yi H, Qiu W, Lu Z, Cai W.   +12 more
europepmc   +2 more sources

The Logic behind Quine's Criterion of Ontological Commitment

, 2020
This article first explains why Quine took first‐order classical logic to be the only language in which we should formulate a theory or declarative statement to determine its ontological commitments.
Jeroen Smid, Smid, Jeroen
core   +1 more source

The Fuzziness of Financial Measurement: An Exploration of the Logic of Accounting’s Indeterminacy

, 2023
Financial measurement is fuzzy: questions about the values ofassets and liabilities and of surpluses and deficits often havea wide range of more or less equally plausible answers.
Timothy Irwin (8513730)
core   +1 more source

Phase Separation of Nucleic Acids: Mechanisms, Properties, and Applications. [PDF]

Angew Chem Int Ed Engl
Recent discoveries have shown that single‐stranded long‐chain nucleic acids can undergo temperature‐induced phase separation, enabling formation of micrometer‐sized condensates. This Minireview discusses the current mechanistic understanding of this phenomenon, highlights strategies for controlling the physical and chemical properties of these ...
Chen W, Fritzen J, Walther A.
europepmc   +2 more sources

Vaguely defined objects: representations, fuzzy sets and nonclassical cardinality theory

, 1996
In recent years, an impetuous development of new, unconventional theories, methods, techniques and technologies in computer and information sciences, systems analysis, decision-making and control, expert systems, data modelling, engineering, etc ...
Wygralak, Maciej
core   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source