Results 101 to 110 of about 3,181,655 (303)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Higgs diphoton rate enhancement from supersymmetric physics beyond the MSSM

, 2012
We show that supersymmetric "new physics" beyond the MSSM can naturally accommodate a Higgs mass near 126 GeV and enhance the signal rate in the Higgs to diphoton channel, while the signal rates in all the other Higgs decay channels coincide with ...
Berg, Marcus, Buchberger, Igor, Ghilencea, D. M., Petersson, Christoffer   +3 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

The first dozen years of the history of ITEP Theoretical Physics Laboratory

, 2012
The theoretical investigations at ITEP in the years 1945-1958 are reviewed. There are exposed the most important theoretical results, obtained in the following branches of physics: 1) the theory of nuclear reactors on thermal neutrons; 2) the hydrogen ...
A.A. Abrikosov, A.B. Migdal, A.D. Galanin, A.D. Galanin, A.I. Akhiezer, B. Wentzel, B. Wentzel, B.L. Ioffe, B.L. Ioffe, B.L. Ioffe, B.L. Ioffe, B.L. Ioffe, B.L. Ioffe, B.L. Ioffe, B.L. Ioffe, B.L. Ioffe, C.S. Wu, D.D. Ivanenko, D.D. Osherov, D.D. Osherov, E. Fermi, E.L. Feinberg, G.A. Goncharov, G.V. Skornyakov, I. Pomeranchuk, I.I. Gurevich, I.Ya. Pomeranchuk, I.Ya. Pomeranchuk, I.Ya. Pomeranchuk, I.Ya. Pomeranchuk, I.Ya. Pomeranchuk, I.Ya. Pomeranchuk, I.Ya. Pomeranchuk, I.Ya. Pomeranchuk, I.Ya. Pomeranchuk, I.Ya. Pomeranchuk, I.Ya. Pomeranhuk, J. Schwinger, J.H. Christenson, K.A. Ter-Martirosyan, L.A. Arzimovich, L.B. Okun, L.B. Okun, L.B. Okun, L.B. Okun, L.D. Landau, L.D. Landau, L.D. Landau, L.D. Landau, L.D. Landau, L.D. Landau, L.D. Landau, L.D. Landau, M. Gell-Mann, P.A.M. Dirac, R.E. Marshak, R.P. Feynman, S.F. Edwards, S.S. Gershtein, T.D. Lee, T.D. Lee, V.B. Berestetsky, V.B. Berestetsky, V.B. Berestetsky, V.B. Berestetsky, V.G. Gorshkov, V.G. Gorshkov, V.G. Vaks, V.G. Vaks, V.V. Sudakov, V.Ya. Fainberg, Ya.B. Zeldovich   +71 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

An investigation of using Spark generative AI in solving physics concept inventories in English and Chinese: performance and issues

Discover Artificial Intelligence
Generative artificial intelligence (GenAI) has garnered considerable attention across various disciplines, including physics education. Numerous studies have explored the potential of using these tools in physics education by assessing their ...
Natthawin Cho
doaj   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Women in physics: A comparison to science, technology, engineering, and math education over four decades

Physical Review Physics Education Research, 2016
[This paper is part of the Focused Collection on Gender in Physics.] The dearth of women in science, technology, engineering, and math (STEM) fields has been lamented by scholars, administrators, policymakers, and the general public for decades, and the ...
Linda J. Sax, Kathleen J. Lehman, Ramón S. Barthelemy, Gloria Lim   +3 more
doaj   +1 more source