Results 101 to 110 of about 22,563,111 (293)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

An investigation of using Spark generative AI in solving physics concept inventories in English and Chinese: performance and issues

Discover Artificial Intelligence
Generative artificial intelligence (GenAI) has garnered considerable attention across various disciplines, including physics education. Numerous studies have explored the potential of using these tools in physics education by assessing their ...
Natthawin Cho
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Sine power Burr X distribution with estimation and applications in physics and other fields

Open Physics
This article aims to introduce a new three-parameter lifetime distribution called sine power Burr X (SPB-X) distribution. The proposed distribution is obtained by the sine-G class of distributions and the power Burr X distribution.
Elbatal Ibrahim, Almetwally Ehab M., Kayid Mohamed, Shawki Ahmed W., Balogun Oluwafemi Samson, Elgarhy Mohammed   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

HOW E-LEARNING DEMONSTRATES THE FORMATION OF STUDENTS' COGNITIVE ACTIVITY IN THE TEACHING OF QUANTUM PHYSICS

Інформаційні технології і засоби навчання, 2017
The aim of this article is to prove the advisability of using the e-learning of quantum physics in the Moodle environment to help students achieve better success in this difficult subject area.
Ihor V. Korsun
doaj  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Measurement of picosecond timing jitter of segmented photon number resolving detectors with continuous spontaneous parametric down-converted light

JPhys Photonics
We report on an innovative method for the characterization of the timing jitter on a picosecond timescale of single photon detectors and segmented photon number resolving detectors using the quantum properties of continuous spontaneous parametric down ...
Syed Muhammad Junaid Bukhari, Matteo Di Giancamillo, Pasquale Ercolano, Ciro Bruscino, Fabio Auriemma, Martina Peluso, Roberta Satariano, Giovanni Piero Pepe, Paolo Martelli, Mario Martinelli, Daniela Salvoni, Loredana Parlato, Mikkel Ejrnaes   +12 more
doaj   +1 more source

Physics goals of a μ+μ− collider

, 1996
This working group report focuses on the physics potential of μ+μ− colliders beyond what can be accomplished at linear e+e− colliders and the LHC. Particularly interesting possibilities include (i) s‐channel resonance production to discover and study ...
Willis, B., Barger, V., Parsa, Z., Berger, M. S., Gunion, J. F., Hong, W., Oh, S. K., Heusch, C. A., Thun, R., Han, T., Rajpoot, S., Fujii, K.   +11 more
core   +1 more source