Results 91 to 100 of about 7,239,466 (308)

Still mesoendemic onchocerciasis in two Cameroonian community-directed treatment with ivermectin projects despite more than 15 years of mass treatment

open access: yesParasites & Vectors, 2016
Background After more than a decade of community-directed treatment with ivermectin (CDTI) in Centre and Littoral Regions of Cameroon, onchocerciasis endemicity was still high in some communities according to the 2011 epidemiological evaluations.
Guy-Roger Kamga   +9 more
doaj   +1 more source

Cost-effectiveness analysis and its application for policy evaluation for medicine or public health [PDF]

open access: yes
In comparison to the policy for other field, the policy for medicine and public health is to consider the value of life or the value of the quality of life. Quality of life is very well known as a concept of QOL.
Tamie Sugawara, Yasushi Ohkusa
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Applying novel Plasmodium Vivax serological exposure markers to quantify residual malaria transmission in the Philippines through repeated health facility surveys: the SMaRT study protocol

open access: yesBMC Infectious Diseases
Background After decades of progress towards malaria elimination, Plasmodium vivax is now the predominant source of infection and the major obstacle towards elimination in the Asia-Pacific region.
Jhobert Bernal   +8 more
doaj   +1 more source

When Heredity Met the Bacterium: Quarantines in New York and Danzig, 1898-1921 [PDF]

open access: yes, 2001
[Excerpt] Recent careful examinations of American quarantines placed on incoming migrants have found that health officials were potent carries of bigotries rooted in the larger society; but usually historians have not paid sufficient attention to the ...
Korman, Gerd
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Letter to the Editor: Chikungunya Virus Infection—An Update on Chronic Rheumatism in Latin America

open access: yesRambam Maimonides Medical Journal, 2017
To the Editor, The article of Krutikov and Manson1 was interesting. However, no comment was made on the impact and related clinical epidemiology of the chikungunya virus (CHIKV) infection during the 2014–2015 epidemics in Latin America, the most ...
Alfonso J. Rodriguez-Morales
doaj   +1 more source

Shortchanging America's Health 2008: A State-by-State Look at How Federal Public Health Dollars Are Spent [PDF]

open access: yes, 2008
Examines public health indicators in each state, in combination with federal and state funding for programs to promote health. Includes state rankings by funding per capita, percentage of population who are uninsured, disease rates, and other ...
Jeffrey Levi   +2 more
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

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