Results 131 to 140 of about 3,913,903 (385)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Systems medicine, an approach in a framework to guide development of preventative, diagnostic and treatment methods for Covid-19 and other complex or novel diseases

, 2020
The Covid-19 has plunged the world into a pandemic where there is no specific cure yet. Scientists around the world are researching and running trials to find highly effective prevention methods and cure. There are three major existing medical approaches which have developed systematic methods to diagnose ,prevent and treat diseases , the TCM, evidence
openaire   +1 more source

Alginate-Based Biomaterials for Regenerative Medicine Applications

Materials, 2013
Alginate is a natural polysaccharide exhibiting excellent biocompatibility and biodegradability, having many different applications in the field of biomedicine.
Jinchen Sun, H. Tan
semanticscholar   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Mental Health in Jamaica: An approach to awareness and treatment in children [PDF]

, 2014
The awareness, perception and treatment of Autism was studied during a service study abroad class to Petersfield, Jamaica during the winters of 2013 and 2014. The program was developed to gain a basic understanding of the etiology of the disorder, and to
Curran, Sam, Naqvi, Lilly
core   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The dialogue with farmers [PDF]

, 2011
This report covers the project outcome Deliverable 4.2 ‘Analysis completed after a joint effort to identify possibilities in each country as how to facilitate the best possible dialogue regarding animal health and welfare’ as part of the European CORE ...
Brinkmann, Jan, Gratzer, Elisabeth, Henriksen, Britt I. F., Ivemeyer, Silvia, Leeb, Christine, March, Solveig, Mejdell, Cecilie, Nicholas, Phillipa, Roderick, Stephen, Smolders, Gidi, Stöger, Elisabeth, Vaarst, Mette, Walkenhorst, Michael, Whistance, Lindsay, Winckler, Christoph   +14 more
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Antimicrobial, antibiofilm, cytotoxicity, and substantivity of aged garlic extract against oral bacteria: an in-vitro study

BMC Complementary Medicine and Therapies
Background Garlic (Allium sativum L.) is a powerful antimicrobial, antioxidant, and anti-inflammatory agent. Aged garlic has more antioxidant and antimicrobial properties compared to fresh garlic.
Meghana Sunil, Bhaskar Kurangi, Suneel Dodamani, Marwa Khalil, Aditi Chopra   +4 more
doaj   +1 more source