Results 141 to 150 of about 3,661,970 (379)

Creating the Health Care Team of the Future: The Toronto Model for Interprofessional Education and Practice [PDF]

, 2014
[Excerpt] In 2000, the Institute of Medicine\u27s landmark report To Err Is Human launched the contemporary patient safety movement with its clarion call to the health care systems all over the globe to act to prevent the errors that kill over 100,000 ...
Hodges, Brian D, Nelson, Sioban, Tassone, Maria   +2 more
core   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Assessing the Unseen: Roles of Confidentiality and Trust in Software Engineering Work-based Learning Programmes [Poster] [PDF]

, 2018
A typical academic degree focused on software engineering has little practical relationship with the industry it is named for, other than the occasional placement or internship. Unlike other professions such as medicine, dentistry and veterinary sciences,
Cutts, Quintin, Draper, Steve, Maguire, Joseph   +2 more
core  

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

PARTICULARITIES OF THE LOGISTIC OPERATIONS IN THE PHARMACEUTICAL DOMAIN [PDF]

The management of logistic operations has a very important role in the case of pharmaceutical products. The purpose of this article is to analyze the particularity of the logistic operations management in the pharmaceutical domain.
BUTNARU, Ana, ŞERBULESCU, Luminiţa
core  

A Metabolomics Study of the Volatile Oil from Prunella vulgaris L. on Pelvic Inflammatory Disease

Digital Chinese Medicine, 2020
Objective: Pelvic inflammatory disease (PID) is one of the most common gynaecological diseases. Here, this thesis aims to investigate the therapeutic effects of Prunella vulgaris L.
Deng Jing, Su Qian, Lin Xiu-Lian, Lin Yan, Li Ya-Mei, Lin Li-Mei, Liao Duan-Fang, Xia Bo-Hou   +7 more
doaj  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Optically-isotropic responses induced by discrete rotational symmetry of nanoparticle clusters

, 2013
Fostered by the recent progress of the fields of plasmonics and metamaterials, the seminal topic of light scattering by clusters of nanoparticles is attracting enormous renewed interest gaining more attention than ever before.
Hopkins, Ben, Kivshar, Yuri S., Liu, Wei, Miroshnichenko, Andrey E.   +3 more
core   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source