Results 161 to 170 of about 3,865,257 (306)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Current status and challenges of the psychiatric nosography. Is there a conflict between expectations and evidence?

Psihiatru.ro
Octavian Vasiliu, Andrei G. Mangalagiu, Bogdan M. Petrescu, Adela M. Ciobanu   +3 more
doaj   +1 more source

Twenty-First Century Data Systems: Evolving Cancer Registries to a Learning Health System. [PDF]

Learn Health Syst
Yu PP, Campbell WS, Durbin EB, Shulman LN, Warner JL.   +4 more
europepmc   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Normal and pathological personality traits – criteria and current challenges

Psihiatru.ro
Aurel Nireștean, Lorena-Mihaela Grebenișan, Bianca-Maria Moldovan, Emese Lukacs   +3 more
doaj   +1 more source

Towards precision medicine in Tourette syndrome: a perspective on AI-driven predictive modelling and personalised care. [PDF]

Front Comput Neurosci
Zhao C, Li R, Hua L, Li H, Zhang M, Wang B.   +5 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The influence of psychiatric disorders on heart failure

Psihiatru.ro
Raluca Pretorian
doaj   +1 more source

Supporting street medicine through medical informatics: a manifesto on research needs. [PDF]

BMJ Health Care Inform
Winter AF, Alverà A, Ammenwerth E, Breaz AM, Chronaki C, Crişan-Vida M, Delgado J, Gallos P, Jahn F, Plicka P, Schneider B, Speerforck S, Stoicu-Tivadar L.   +12 more
europepmc   +1 more source