Results 151 to 160 of about 3,913,903 (385)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Insights into the antiviral mechanisms of β-caryophyllene: inhibiting viral spread and its synergy with acyclovir

BMC Complementary Medicine and Therapies
Background HSV-1 infections are pervasive in the general population of the world, and the gradual development of resistance to conventional antiviral therapies underlines the need to investigate alternative therapies.
Mohammad Yasaghi, Sahar Beryani Dolatabadi, Ahad Yamchi, Alijan Tabarraei, Abdolvahab Moradi, Seyedeh Delafruz Hosseini   +5 more
doaj   +1 more source

Implementing an Integrated Pharmaceutical Management Information System for Antiretrovirals and Other Medicines: Lessons From Namibia [PDF]

, 2018
David Mabirizi, Bayobuya Phulu, Wuletaw Churfo, Samson Mwinga, Greatjoy Mazibuko, Evans Sagwa, Lazarus Indongo, Tamara Hafner   +7 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Royal jelly alleviates gemcitabine-induced ovarian toxicity: an investigation on rat models

BMC Complementary Medicine and Therapies
Background Royal Jelly (RJ), an important product of apitherapy, has been traditionally used for its various health benefits, particularly for its anti-inflammatory, antioxidant, and immune-modulatory properties.
Kubra Tuğce Kalkan, Betul Yalcin, Halime Tozak Yildiz, Ertan Katirci, Eda Koseoglu, Demet Bolat, Arzu Yay   +6 more
doaj   +1 more source

Assisted Reproductive Technologies, Other New Frontiers in Medicine, and the Income Tax's Role as a Backup Health Insurance System

, 2023
Daniel Shaviro
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Integrating network pharmacology and multi-omics in a systems approach: a mechanism study of Jinhong tablets against chronic superficial gastritis

Chinese Medicine
Background Chronic gastritis (CG) significantly impacts patients’ quality of life and can progress to more severe gastric conditions. In China, Traditional Chinese Medicine (TCM) has been widely applied for its holistic efficacy in treating chronic ...
Lihao Xiao, Tingyu Zhang, Yun Liu, Chayanis Sutcharitchan, Qingyuan Liu, Xiaoxue Fan, Jian Feng, Huifang Gao, Shao Li, Tong Zhang   +9 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Efficacy and safety of Wuling capsule for the treatment of mild depression in patients with early Parkinson’s disease in China: a randomized clinical trial

BMC Complementary Medicine and Therapies
Background Depression is a prevalent non-motor symptom of Parkinson’s disease (PD) that significantly impacts patients’ quality of life. The Wuling capsule, a traditional Chinese medicine, is often utilized for treating depression, and this herbal ...
Yuwen Zhao, Lin Li, Dongya Huang, Wentao Li, Qiuyan Zhao, Huiqin Liu, Ran Xiong, Meijuan Liu, Jing Gan, Na Wu, Zhihua Liu, Xinxin Chen, Shizheng Zhang, Huina Feng, Jinfeng Lu, Xiaodan Chen, Yu Zhang, Xiaohui Zhao, Zhenguo Liu   +18 more
doaj   +1 more source